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The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
Glutaric Acid is a C5 dicarboxylic acid and an intermediate in the catabolic pathways of tryptophan and lysine. It affects the contractility and migration of pericytes and serves as a biomarker for type I glutaric aciduria.
Synonyms: GA
4.5
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Batch number can be found on the product's label following the word 'Batch'.
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Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
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CAS No. : | 110-94-1 |
Formula : | C5H8O4 |
M.W : | 132.11 |
SMILES Code : | O=C(O)CCCC(O)=O |
Synonyms : |
GA
|
MDL No. : | MFCD00004410 |
InChI Key : | JFCQEDHGNNZCLN-UHFFFAOYSA-N |
Pubchem ID : | 743 |
GHS Pictogram: |
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Signal Word: | Warning |
Hazard Statements: | H315-H319-H302 |
Precautionary Statements: | P264-P280-P302+P352-P312-P337+P313-P305+P351+P338-P362+P364-P332+P313 |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
100% | 1.8 g of (R, R) -N,N'-bis (3, 5-di-t-butylsalicylidene) -1,2- cyclohexanediamine and 1.1 g of cobalt (II) acetate-4H2O were mixed in 35 ml of ethanol and stirred under reflux for 5 hours. They were filtered at room temperature and cleaned by small amount of ethanol. The obtained solid was uniformly divided into four parts and mixed with 6 ml of acetone and 10 ml of dichloromethane respectively. Also, 1.0 equivalent weight of succinic acid, glutaric acid, adipic acid, and pimeric acid were added respectively and stirred for 3 hours with injection of air at room temperature. After the solvent was eliminated under reduced pressure, the title compounds were obtained quantitatively. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In ethanol; dichloromethane; at 20℃; for 24h; | Example 23: Preparation of aliskiren glutaric acid salt <strong>[173334-57-1]Aliskiren</strong> (1.6 g, 2.9 mmol) was dissolved in dichloromethane (10 mL), and glutaric acid (0.191 g, 1.45 mmol) in ethanol (1 mL) was added while stirring. The solution was stirred at room temperature for 24 h. Then, the solvent was evaporated in vacuum and the product was dried under vacuum at 30C over night. Mp = 71.5-75.8C XRPD: amorphous |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
46% | With sodium hydroxide; In ethanol; at 110.0℃; for 72h;pH 7.0;Autoclave; | General procedure: A solution of H2fum (0.2 mmol) or H2glu (0.2 mmol) in 5 mL H2O was adjusted to pH7 with dilute NaOH. Then bix (0.2 mmol) in 5 mL EtOH and CdCl2·2.5H2O (0.2 mmol) in 5 mL H2O were added. The mixture was added to a 30 mL Teflon-lined stainless autoclave and this was sealed and heated to 110C for 3days and then cooled to room temperature to give the colorless crystals 1 in 38% yield based on Cd(II) (0.036 g) or 2 in 46% yield based on Cd(II) (0.035 g). Anal. calcd. for C36H39Cd2Cl2N8O4.50 (1) C, 45.45; H, 4.13; N, 11.78. Found: C, 45.39%; H, 4.08%; N, 11.74%. Anal. calcd. for C26H30Cd2N4O8 (2) C, 41.56; H, 4.02; N, 7.46. Found: C, 41.53%; H, 3.97%; N,7.44 %. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
53% | With sodium hydroxide; In ethanol; water; at 90.0℃; for 72h;pH 7.0;Autoclave; | General procedure: A solution of H2ndc (0.2mmol) in 8mL H2O was adjusted to pH 7 with dilute NaOH. Then bix (0.2mmol) in 7mL EtOH and Co(NO3)2·6H2O (0.2mmol) in 7mL H2O were added. The mixture was added to a 30mL Teflon-lined stainless autoclave and it was sealed and heated to 90C for 3days, then cooled to room temperature to give red crystals of 1 in 56% yield (0.060g). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
47% | With sodium hydroxide; In ethanol; water; at 90.0℃; for 72h;Autoclave; High pressure; | General procedure: The solution of bix (0.2 mmol) in 5 mL EtOH and Cd(NO3)2.6H2O(0.2 mmol) in 5 mL H2O were added to H2mbda (0.20 mmol) andNaOH (0.18 mmol) in 5 mL H2O. The mixture was added to a30 mL Teflon-lined stainless autoclave and this was sealed and heated to 90 C for 3 days and then cooled to room temperature to give the colorless crystals 3 (Yield: 0.064 g, 56% based on H2-mbda ligand). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
46% | A mixture of glutaric acid (0.061 g,0.5 mmol), Ni(NO3)26H2O (0.145 g, 0.5 mmol), 1,4-mbix(0.134 g, 0.5 mmol) and water (10 ml) was stirred for 30 min.The pH of the mixture was adjusted to 6.0 with 1 mol l1NaOH solution and the resulting mixture was transferred toand sealed in a 25 ml Teflon-lined stainless steel container andheated at 160 C for 3 d. After slow cooling to room temperature,green block-shaped crystals of (I) were collected in 46%yield (based on the NiII salt). Elemental analysis (%) calculatedfor C42H54N8Ni2O11: C 52.31, H 5.64, N 11.62; found: C 52.18, H 5.71, N 11.48. IR (KBr, cm1): 3411 (s), 3136 (w), 2940(w), 1636 (w), 1616 (s), 1557 (w), 1517 (w), 1454 (w), 1398 (s),1271 (w), 1104 (w), 910 (w), 805 (w), 740 (m), 611 (w). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
62% | General procedure: A mixture of glutaric acid (0.061 g,0.5 mmol), Ni(NO3)26H2O (0.145 g, 0.5 mmol), 1,4-mbix(0.134 g, 0.5 mmol) and water (10 ml) was stirred for 30 min.The pH of the mixture was adjusted to 6.0 with 1 mol l1NaOH solution and the resulting mixture was transferred toand sealed in a 25 ml Teflon-lined stainless steel container andheated at 160 C for 3 d. After slow cooling to room temperature,green block-shaped crystals of (I) were collected in 46%yield (based on the NiII salt). |