The TACC family (Transforming Acidic Coiled-Coil Proteins) includes three main members: TACC1, TACC2, and TACC3. These proteins feature an acidic coiled-coil structure and are mainly localized in the nucleus and centrosomes. TACC proteins are involved in cell division by stabilizing microtubules and regulating spindle dynamics. Specific expression of TACC genes varies significantly across tissues, and abnormal expression is associated with the development of various cancers. Mutations can lead to cell cycle dysregulation and mitotic errors, increasing the risk of carcinogenesis.