Home Chemistry Organic Building Blocks Fluorinated Building Blocks 3,4-Difluoroaniline
These compounds have the same murcko framework: benzene,and at least 2 kinds of functional groups( —F,—NH2).
Electrophilic Aromatic Substitution (EAS): Fluorobenzene can undergo typical electrophilic aromatic substitution reactions, similar to benzene. The fluorine atom, being electron-withdrawing, can influence the reactivity of the benzene ring. Common EAS reactions include nitration, halogenation, sulfonation, and Friedel-Crafts reactions.
Reimer-Tiemann Reaction: Aniline can react with chloroform (CHCl3) and a base to undergo the Reimer-Tiemann reaction, leading to the formation of a salicylaldehyde derivative.
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3,6-Dibromo-4,5-difluorobenzene-1,2-diamine
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2,3,4,5,6-Pentafluoroaniline trifluoromethanesulfonate
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