Home Chemistry Heterocyclic Building Blocks Indazoles 1H-Indazol-4-Ol
Substitution Reactions: The hydroxyl group can undergo substitution reactions, such as nucleophilic substitution, electrophilic substitution, or substitution with leaving groups, leading to the formation of substituted indazoles.
Oxidation: The hydroxyl group can be oxidized to form the corresponding carbonyl compound (ketone or aldehyde) or carboxylic acid under appropriate conditions.
Nucleophilic Addition: The double bond between the carbon atoms in the indazole ring can undergo nucleophilic addition reactions with various nucleophiles, leading to functionalized derivatives.
Esterification: The hydroxyl group can react with carboxylic acids or acid derivatives to form esters through esterification reactions.
Amidation: The hydroxyl group can react with amines or ammonia to form amides.
Reduction: The carbonyl group can be reduced to the corresponding alcohol using reducing agents such as lithium aluminum hydride or sodium borohydride.
Condensation Reactions: It can participate in condensation reactions with carbonyl compounds or other nucleophiles to form cyclic compounds or larger molecules.
Protonation: The hydroxyl group can be protonated under acidic conditions to form the corresponding oxonium ion.
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