Home Chemistry Organic Building Blocks Fluorinated Building Blocks 2-Fluoro-4-Methyl-1-Nitrobenzene
These compounds have the same murcko framework: benzene,and at least 3 kinds of functional groups( —F,—NO2,—CH3).
Fluorine Substitution: Fluorobenzene can undergo further substitution reactions to replace the fluorine atom with other functional groups. This can be achieved through nucleophilic aromatic substitution reactions. The electron-withdrawing nature of fluorine can affect the regioselectivity and reactivity of such substitutions.
Reduction: The nitro group in nitrobenzene can be reduced to an amino group (-NH2) using reducing agents like iron and hydrochloric acid, or more commonly, using catalytic hydrogenation. This reaction produces aniline.
Halogenation: Toluene can undergo halogenation reactions with halogens (such as chlorine or bromine) in the presence of a catalyst or under UV light. The hydrogen atoms on the benzene ring can be replaced by halogen atoms, resulting in the formation of mono-, di-, or polyhalogenated derivatives of toluene.
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1-Fluoro-3-methoxy-5-methyl-2-nitrobenzene
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2-Bromo-3-fluoro-1-methyl-4-nitrobenzene
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Methyl 4-fluoro-2-methyl-5-nitrobenzoate
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1-Bromo-4-fluoro-2-methyl-5-nitrobenzene
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