The elastase family comprises various serine proteases primarily expressed in neutrophils and certain tissue cells, responsible for degrading elastin and various other proteins. These enzymes play a crucial role in extracellular matrix remodeling, inflammation, and tissue repair. Family members such as pancreatic elastase and neutrophil elastase exhibit specific expression in tissues such as the lungs and skin, participating in multiple signaling pathways, such as regulating cell migration and immune responses. Gene mutations or dysregulated expression are associated with various diseases such as emphysema, chronic obstructive pulmonary disease (COPD), and certain skin conditions.