FLAP (5-Lipoxygenase-Activating Protein) is a membrane-bound protein crucial in the leukotriene synthesis pathway, aiding in the conversion of arachidonic acid to leukotriene precursors by 5-lipoxygenase. FLAP is primarily expressed in leukocytes such as neutrophils, eosinophils, and macrophages, located on the intracellular membrane. By participating in leukotriene generation during inflammatory responses, FLAP influences various biological processes including inflammation, immune responses, and cell signaling. Specific gene expression and mutations of FLAP are associated with asthma, atherosclerosis, and other inflammation-related diseases. Therefore, FLAP serves as an important target for anti-inflammatory therapy and disease research.