Home Chemistry Heterocyclic Building Blocks Phthalazines Phthalazine
Aromatic Substitution: Phthalazine is an aromatic compound, so it can undergo electrophilic aromatic substitution reactions, such as nitration, sulfonation, halogenation, and Friedel-Crafts reactions. These reactions can modify the aromatic rings in the molecule.
Reduction: Phthalazine can be reduced to form 1,2,3,4-tetrahydrophthalazine by using reducing agents like hydrogen and a metal catalyst (e.g., palladium).
Oxidation: Phthalazine can be oxidized to phthalazinone or other derivatives using various oxidizing agents like potassium permanganate.
Nucleophilic Substitution: The nitrogen atom in phthalazine can act as a nucleophile in certain reactions. It can undergo nucleophilic substitution with various electrophiles, leading to the formation of different compounds.
Alkylation and Acylation: Phthalazine can undergo alkylation and acylation reactions when treated with appropriate alkylating or acylating agents, leading to the introduction of alkyl or acyl groups on the nitrogen atom or the aromatic rings.
Hydrogenation: Phthalazine can be hydrogenated using hydrogen and a suitable catalyst to form the saturated dihydrophtalazine.
Ring-Cleavage Reactions: Under certain conditions, phthalazine can undergo ring-cleavage reactions, leading to the formation of various products.
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1,4-Dichlorophthalazine-6-carbonitrile
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