Home Chemistry Organic Building Blocks Chlorides 3-Chloro-2-Fluorobenzoic Acid
These compounds have the same murcko framework: benzene,and at least 3 kinds of functional groups( —Cl,—F,—COOH).
Electrophilic Substitution Reactions: Chlorobenzene's electron-rich aromatic ring can undergo substitution reactions where a hydrogen atom is replaced by a chlorine atom. For instance, it can undergo nitration, sulfonation, and Friedel-Crafts alkylation/acylation reactions.
Cross-Coupling Reactions: Fluorobenzene can be utilized in cross-coupling reactions, such as Suzuki-Miyaura, Negishi, and Stille reactions. These reactions involve coupling a halogenated aromatic compound with an organometallic reagent, resulting in the formation of new carbon-carbon bonds.
Friedel-Crafts Acylation: Benzoic acid can undergo Friedel-Crafts acylation reactions with aromatic compounds in the presence of a Lewis acid catalyst such as aluminum chloride (AlCl3). This reaction results in the introduction of an acyl group (RCO-) onto the aromatic ring.
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3-Chloro-2-fluoro-5-(trifluoromethyl)benzoic acid
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3-Chloro-2-fluoro-6-(trifluoromethyl)benzoic acid
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