RAGE (Receptor for Advanced Glycation End Products) is a member of the immunoglobulin superfamily, containing a transmembrane structure and an extracellular domain used to recognize various ligands, such as AGEs, S100 proteins, and HMGB1. RAGE is mainly expressed in vascular endothelial cells, immune cells, and neurons. By activating signaling pathways such as NF-κB, RAGE is involved in biological responses such as inflammation, oxidative stress, and cell apoptosis. The expression of the RAGE gene is tissue-specific, and its overactivation or mutations are associated with various diseases, including diabetes, cardiovascular diseases, Alzheimer's disease, and cancer.