Chemistry Organic Building Blocks Ketones 1,3-Dioxoisoindolin-2-Yl 2-Phenylacetate

1,3-Dioxoisoindolin-2-Yl 2-Phenylacetate

Hydrolysis: The ester functional group in 1,3-dioxoisoindolin-2-yl 2-phenylacetate can undergo hydrolysis in the presence of an acid or base to yield the corresponding carboxylic acid and alcohol. Reduction: The carbonyl groups (dioxo groups) in the isoindolinone ring can be reduced to form the corresponding alcohol groups using reducing agents like sodium borohydride (NaBH4) or lithium aluminum hydride (LiAlH4). Acylation: The compound can undergo acylation reactions with acyl chlorides or anhydrides in the presence of a base to introduce new substituents at the amino or hydroxyl groups. Substitution Reactions: The phenyl group and other substituents can undergo various substitution reactions, such as electrophilic aromatic substitution or nucleophilic aromatic substitution, depending on the reaction conditions. Cyclization: Depending on the reaction conditions and reagents, cyclization reactions may occur, leading to the formation of cyclic compounds. Oxidation: The compound can undergo oxidation reactions to convert functional groups to their respective oxidation states, depending on the choice of oxidizing agent. Ring Opening: The isoindolinone ring can potentially undergo ring-opening reactions under specific conditions, leading to the formation of open-chain compounds.

Further Reading:

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(1E,4E)-1,5-Diphenylpenta-1,4-Dien-3-One (1E,6E)-1,7-Diphenylhepta-1,6-Diene-3,5-Dione (2-Aminophenyl)(Phenyl)Methanone (2-Bromophenyl)(Phenyl)Methanone (2-Chlorophenyl)(Phenyl)Methanone (2-Fluorophenyl)(Phenyl)Methanone (2-Hydroxyphenyl)(Phenyl)Methanone (2-Iodophenyl)(Phenyl)Methanone (3-Chlorophenyl)(Phenyl)Methanone (3-Fluorophenyl)(Phenyl)Methanone (3-Nitrophenyl)(Phenyl)Methanone (4-Aminophenyl)(Phenyl)Methanone (4-Bromophenyl)(Phenyl)Methanone (4-Chlorophenyl)(Phenyl)Methanone (4-Fluorophenyl)(Phenyl)Methanone (4-Hydroxyphenyl)(Phenyl)Methanone (4-Methoxyphenyl)(Phenyl)Methanone (4-Nitrophenyl)(Phenyl)Methanone (8S,14R)-6,7,8,9,10,11,12,13,14,15,16,17-Dodecahydro-3H-Cyclopenta[A]Phenanthren-3-One (E)-1-(2-Hydroxyphenyl)-3-Phenylprop-2-En-1-One (R)-5-Thia-1-Azabicyclo[4.2.0]Oct-2-En-8-One 1,3-Dioxoisoindolin-2-Yl 2-Phenylacetate 1,3-Diphenylpropan-1-One 1,4-Diazepan-5-One 1,4-Dihydroisoquinolin-3(2H)-One 1-(1H-Indazol-1-Yl)Ethan-1-One 1-(1H-Indol-1-Yl)Ethan-1-One 1-(1H-Indol-3-Yl)Ethan-1-One 1-(1H-Pyrrolo[2,3-B]Pyridin-3-Yl)Ethan-1-One 1-(2-(Trifluoromethyl)Phenyl)Ethan-1-One 1-(2-Aminophenyl)Ethan-1-One 1-(2-Bromophenyl)Ethan-1-One 1-(2-Chlorophenyl)Ethan-1-One 1-(2-Fluorophenyl)Ethan-1-One 1-(2-Hydroxyphenyl)-2-Phenylethan-1-One 1-(2-Hydroxyphenyl)-3-Phenylprop-2-En-1-One 1-(2-Hydroxyphenyl)Ethan-1-One 1-(2-Iodophenyl)Ethan-1-One 1-(2-Methoxyphenyl)Ethan-1-One 1-(2-Nitrophenyl)Ethan-1-One 1-(3-(Benzyloxy)Phenyl)Ethan-1-One 1-(3-Aminophenyl)Ethan-1-One 1-(3-Chlorophenyl)Ethan-1-One 1-(3-Fluorophenyl)Ethan-1-One 1-(3-Hydroxyphenyl)Ethan-1-One 1-(3-Iodophenyl)Ethan-1-One 1-(3-Methoxy-2-Nitrophenyl)Ethan-1-One 1-(3-Methoxyphenyl)Ethan-1-One 1-(3-Nitrophenyl)Ethan-1-One 1-(3-Nitrophenyl)Propan-1-One 1-(4-(Benzyloxy)Phenyl)Ethan-1-One 1-(4-Fluorophenyl)Ethan-1-One 1-([1,1'-Biphenyl]-4-Yl)Ethan-1-One 1-(Benzofuran-2-Yl)Ethan-1-One 1-(Imidazo[1,2-A]Pyridin-3-Yl)Ethan-1-One 1-(M-Tolyl)Ethan-1-One 1-(Naphthalen-2-Yl)Ethan-1-One 1-(O-Tolyl)Ethan-1-One 1-(Piperidin-1-Yl)Ethan-1-One 1-(Pyrazin-2-Yl)Ethan-1-One 1-(Pyridin-2-Yl)Ethan-1-One 1-(Pyridin-3-Yl)Ethan-1-One 1-(Pyridin-4-Yl)Ethan-1-One 1-(Pyrimidin-2-Yl)Ethan-1-One 1-(Pyrimidin-4-Yl)Ethan-1-One 1-(Pyrrolidin-1-Yl)Ethan-1-One 1-(Thiazol-2-Yl)Ethan-1-One 1-(Thiophen-2-Yl)Ethan-1-One 1-Aminoanthracene-9,10-Dione 1-Benzylindoline-2,3-Dione 1-Benzylpiperidin-3-One 1-Chloroanthracene-9,10-Dione 1-Hydroxyanthracene-9,10-Dione 1-Methylpiperazin-2-One 1-Methylpyrrolidin-2-One 1-Phenylbutan-1-One 1-Phenylpentan-1-One 1-Phenylpiperidin-2-One 1-Phenylpropan-2-One 2,2,2-Trifluoro-1-Phenylethan-1-One 2,2-Dimethyl-1-Phenylpropan-1-One 2,2-Dimethyl-2H-Benzo[B][1,4]Oxazin-3(4H)-One 2,3,4,9-Tetrahydro-1H-Carbazol-1-One 2,3-Dihydrofuran-3-One 2,3-Dihydropyridin-2-One 2,5-Dichlorobenzoic Acid 2-Amino-1-(Pyrrolidin-1-Yl)Ethan-1-One 2-Benzalacetophenone 2-Benzoylbenzoic Acid 2-Chloro-1-Phenylethan-1-One 2-Chlorocyclohexa-2,5-Diene-1,4-Dione 2-Chloroquinazolin-4(3H)-One 2-Hydroxy-1,2-Diphenylethan-1-One 2-Hydroxy-1-Phenylethan-1-One 2-Hydroxycyclohexa-2,5-Diene-1,4-Dione 2-Hydroxyquinolin-4(1H)-One 2-Methoxycyclohexa-2,5-Diene-1,4-Dione 2-Methyl-1-Phenylpropan-1-One 2-Methyl-2H-Benzo[B][1,4]Oxazin-3(4H)-One 2-Methyl-3,4-Dihydroisoquinolin-1(2H)-One 2-Methylcyclohexa-2,5-Diene-1,4-Dione 2-Methylcyclohexan-1-One 2-Methylisoindolin-1-One 2-Methylisoindoline-1,3-Dione 2-Methylpyridazin-3(2H)-One 2-Oxo-2-Phenylacetaldehyde 2-Oxo-2-Phenylacetic Acid 3,3-Difluoropiperidin-4-One 3,3-Dimethylcyclohexan-1-One 3,3-Dimethylpiperidin-4-One 3,4-Dihydroquinoxalin-2(1H)-One 3-Acetyl-2H-Chromen-2-One 3-Aminopyrrolidin-2-One 3-Bromo-1H-Pyrrole-2,5-Dione 3-Chloro-1-Phenylpropan-1-One 3-Fluoropiperidin-4-One 3-Hydroxy-2-Phenyl-4H-Chromen-4-One 3-Hydroxypyrrolidin-2-One 3-Methylcyclohexan-1-One 3-Methylene-2,3-Dihydro-1H-Inden-1-One 3-Methylpiperazin-2-One 3-Methylpyrimidin-4(3H)-One 3-Oxo-3-Phenylpropanenitrile 3-Oxo-N-Phenylbutanamide 3-Phenyl-1-(Pyrrolidin-1-Yl)Propan-1-One 3-Phenyl-2-Thioxoimidazolidin-4-One 3-Phenylacrylaldehyde 3-Phenylimidazolidine-2,4-Dione 4,4,4-Trifluoro-1-Phenylbutane-1,3-Dione 4-(1,2,2-Triphenylvinyl)Benzaldehyde 4-(Hydroxymethyl)Pyrrolidin-2-One 4-Benzylmorpholin-3-One 4-Bromoisoindolin-1-One 4-Bromopyridazin-3(2H)-One 4-Chloro-1-Phenylbutan-1-One 4-Chloropyridazin-3(2H)-One 4-Fluoroindoline-2,3-Dione 4-Hydroxy-2H-Chromen-2-One 4-Hydroxydihydrofuran-2(3H)-One 4-Hydroxypiperidin-2-One 4-Hydroxypyrrolidin-2-One 4-Methyl-2H-Chromen-2-One 4-Methylisobenzofuran-1(3H)-One 4-Oxo-4-Phenylbutanoic Acid 4-Phenylbutan-2-One 4-Phenylcyclohexan-1-One 4-Phenylmorpholin-3-One 4-Phenylpyrrolidin-2-One 5,6-Dihydrobenzo[D]Thiazol-7(4H)-One 5-(Aminomethyl)Pyrrolidin-2-One 5-(Hydroxymethyl)Pyrrolidin-2-One 5-Bromoisoindolin-1-One 5-Bromoisoindoline-1,3-Dione 5-Bromopyrimidin-4(3H)-One 5-Chloroisoindoline-1,3-Dione 5-Chloropyrimidin-4(3H)-One 5-Chloropyrimidine-2,4(1H,3H)-Dione 5-Fluoro-3,4-Dihydronaphthalen-1(2H)-One 5-Fluorochroman-4-One 5-Fluoroindolin-2-One 5-Fluoroisoindolin-1-One 5-Fluoropyrimidin-4(3H)-One 5-Fluoropyrimidine-2,4(1H,3H)-Dione 5-Hydroxy-2-Phenyl-4H-Chromen-4-One 5-Hydroxypiperidin-2-One 5-Methoxy-2-Phenyl-4H-Chromen-4-One 5-Methyl-3,4-Dihydronaphthalen-1(2H)-One 5-Methylindolin-2-One 5-Oxopyrrolidine-2-Carboxylic Acid 6-Bromoisoindolin-1-One 6-Fluorochroman-4-One 6-Fluoroindoline-2,3-Dione 6-Fluoroisobenzofuran-1(3H)-One 6-Hydroxy-2,3-Dihydro-1H-Inden-1-One 6-Methoxy-2,3-Dihydro-1H-Inden-1-One 6-Methoxy-3,4-Dihydronaphthalen-1(2H)-One 6-Methoxyisoindolin-1-One 6-Methyl-2,3-Dihydro-1H-Inden-1-One 7,8-Dihydroquinolin-5(6H)-One 7-(Diethylamino)-2H-Chromen-2-One 7-Bromo-3,4-Dihydronaphthalen-1(2H)-One 7-Bromochroman-4-One 7-Bromoindoline-2,3-Dione 7-Bromoquinazolin-4(3H)-One 7-Chloro-3,4-Dihydronaphthalen-1(2H)-One 7-Fluorochroman-4-One 7-Fluoroindolin-2-One 7-Fluoroquinazolin-4(3H)-One 7-Hydroxy-2H-Chromen-2-One 7-Methoxy-2H-Chromen-2-One 7-Methoxy-3,4-Dihydronaphthalen-1(2H)-One 7-Methoxychroman-4-One 7-Methylindoline-2,3-Dione 8-Bromochroman-4-One 8-Fluoro-3,4-Dihydronaphthalen-1(2H)-One 8-Fluoroisoquinolin-1(2H)-One 8-Methylchroman-4-One Acetophenone Azepan-2-One Benzo[Cd]Indol-2(1H)-One Benzofuran-2(3H)-One Chroman-2-One Cyclobutanone Cyclohex-2-En-1-One Cyclohexane-1,3-Dione Cyclopent-2-En-1-One Cyclopentane-1,3-Dione Dihydro-2H-Pyran-2,6(3H)-Dione Dihydrofuran-2,5-Dione Dihydrofuran-3(2H)-One Dihydrothiophen-3(2H)-One Ethene-1,1-Diyldibenzene Ethyl 2-Oxo-2-Phenylacetate Ethyl 3-Oxo-3-Phenylpropanoate Furan-2(5H)-One Isoquinolin-1-Ol Methyl 3-Oxo-3-Phenylpropanoate Morpholin-3-One Phenyl(3-(Trifluoromethyl)Phenyl)Methanone Phenyl(M-Tolyl)Methanone Phenyl(P-Tolyl)Methanone Phenyl(Pyridin-3-Yl)Methanone Phenyl(Thiophen-2-Yl)Methanone Piperidine-2,4-Dione Propiophenone Pyrimidine-4,6(1H,5H)-Dione Tert-Butyl (2-Oxopiperidin-3-Yl)Carbamate Tert-Butyl (2-Oxopyrrolidin-3-Yl)Carbamate Tert-Butyl (3-Oxocyclohexyl)Carbamate Tert-Butyl (5-Oxopyrrolidin-3-Yl)Carbamate Tert-Butyl (6-Oxopiperidin-3-Yl)Carbamate Tert-Butyl 2-Oxopiperidine-1-Carboxylate Tert-Butyl 2-Oxopyrrolidine-1-Carboxylate Tert-Butyl 4-Oxopiperidine-1-Carboxylate Tetrahydropyrimidin-2(1H)-One

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    (1,3-Dioxoisoindolin-2-yl) 2-(4-isobutylphenyl)propanoate

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    1,3-Dioxoisoindolin-2-yl 2-(4-chlorophenyl)acetate

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    1,3-Dioxoisoindolin-2-yl 2-(4-fluorophenyl)acetate

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