Home Chemistry Organic Building Blocks Iodides 1-Fluoro-2-Iodo-4-Methylbenzene
These compounds have the same murcko framework: benzene,and at least 3 kinds of functional groups( —I,—F,—CH3).
Electrophilic Aromatic Substitution (EAS): Iodobenzene can undergo typical electrophilic aromatic substitution reactions, similar to benzene. The presence of the iodine atom makes the ring more reactive toward electrophiles due to its electron-donating inductive effect. Common EAS reactions include nitration, halogenation, sulfonation, and Friedel-Crafts reactions.
Fluorine Substitution: Fluorobenzene can undergo further substitution reactions to replace the fluorine atom with other functional groups. This can be achieved through nucleophilic aromatic substitution reactions. The electron-withdrawing nature of fluorine can affect the regioselectivity and reactivity of such substitutions.
Alkylation: Similar to acylation, toluene can also undergo Friedel-Crafts alkylation reactions, where an alkyl group is introduced onto the benzene ring. Alkylation reactions also require a Lewis acid catalyst.
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