The AKR (Aldo-Keto Reductase) family is a group of NADPH-dependent enzymes responsible for catalyzing the reduction reaction of aldehydes and ketones. The family includes multiple subtypes, such as AKR1A1, AKR1B1 (Aldose Reductase), and AKR1C1, each with different substrate specificities. They consist of multiple functional domains and are primarily located in the cytoplasm. The AKR family plays a crucial role in regulating the cellular redox state, drug metabolism, and the clearance of endogenous compounds. The expression of AKR family members is tissue-specific, and mutations or dysregulation in their genes are associated with various diseases, including diabetes, cancer, and neurodegenerative diseases.