Adenylyl Cyclase (AC) is a class of enzymes that catalyze the conversion of ATP into cyclic adenosine monophosphate (cAMP). The AC family includes various isoforms, such as AC1 to AC10. These enzymes typically consist of two transmembrane domains and two catalytic domains. AC is primarily located on the cell membrane and participates in G protein-coupled receptor (GPCR) signaling pathways, regulating intracellular cAMP levels and affecting various biological processes, such as metabolism, cell proliferation, and neurotransmission. Mutations or dysregulation of AC genes are associated with the development and progression of heart diseases, neurodegenerative diseases, and certain cancers.