Home Chemistry Organic Building Blocks Trifluoromethyls 3-(Trifluoromethyl)Benzonitrile
These compounds have the same murcko framework: benzene,and at least 2 kinds of functional groups( —CF3,—C≡N).
Nucleophilic Aromatic Substitution (SNAr): Depending on the nature of the nucleophile, nucleophilic aromatic substitution reactions can occur. The trifluoromethyl group can influence the reactivity and regioselectivity of these reactions.
Amination: Benzonitrile can be aminated using various reagents to introduce 【amine|https://www.ambeed.com/amines.html】 functional groups.
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3-Chloro-5-(trifluoromethyl)benzonitrile
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4-Hydrazinyl-3-(trifluoromethyl)benzonitrile
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4-(Aminomethyl)-3-(trifluoromethyl)benzonitrile
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4-Amino-5-(trifluoromethyl)isophthalonitrile
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3-Hydroxy-5-(trifluoromethyl)benzonitrile
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4-Methoxy-3-(trifluoromethyl)benzonitrile
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2,6-Difluoro-3-(trifluoromethyl)benzonitrile
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2-Amino-5-chloro-3-(trifluoromethyl)benzonitrile
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2-Amino-3-bromo-5-(trifluoromethyl)benzonitrile
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2-(Methylsulfonyl)-5-(trifluoromethyl)benzonitrile
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3-Chloro-2-fluoro-5-(trifluoromethyl)benzonitrile
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