Home Chemistry Heterocyclic Building Blocks Indazoles 1-Benzyl-1H-Indazole
Alkylation: Alkylation reactions involve the introduction of alkyl groups onto the indazole ring. For instance, if you react 1-benzyl-1H-indazole with an alkyl halide in the presence of a base, you can alkylate the indazole ring.
Reduction: Reduction reactions can be used to convert the benzyl group into a saturated alkyl group. For example, catalytic hydrogenation with a metal catalyst like palladium on carbon (Pd/C) can reduce the benzyl group to a methyl group.
Nucleophilic Substitution: Depending on the reaction conditions and the substituents present on the benzyl and indazole groups, nucleophilic substitution reactions can occur. This might involve the displacement of a leaving group on the benzyl or indazole ring with a nucleophile.
Oxidation: Oxidation reactions can be used to convert the indazole ring or benzyl group into different functional groups. For example, oxidation of the benzyl group can yield a carboxylic acid or aldehyde.
Halogenation: 1-Benzyl-1H-indazole can undergo halogenation reactions, where halogen atoms (e.g., chlorine, bromine) are introduced onto the indazole or benzyl ring. These reactions typically require the presence of a halogenating agent.
Cyclization: Depending on the reaction conditions and the presence of appropriate functional groups, 1-benzyl-1H-indazole can undergo intramolecular cyclization reactions to form fused ring systems or heterocycles.
Nitration: Under appropriate conditions, you can introduce a nitro group (-NO2) onto the indazole or benzyl ring by using a nitrating agent.
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