Home Chemistry Heterocyclic Building Blocks Piperidines Piperidine-3-Carboxylic Acid
Esterification: Reaction with alcohols in the presence of an acid catalyst to form esters.
Amide Formation: Reaction with amines to form amides, particularly when reacted with primary or secondary amines.
Decarboxylation: Under certain conditions, nipecotic acid can undergo decarboxylation to form piperidine, a process often catalyzed by heat or acid.
Acylation: Reacting with acyl chlorides or anhydrides to introduce acyl groups onto the piperidine nitrogen or carboxylic acid oxygen.
Reduction: Reduction of the carboxylic acid group to the corresponding alcohol using reducing agents such as lithium aluminum hydride (LiAlH4) or borane.
Halogenation: Substitution reactions can occur, where the carboxylic acid group or the piperidine ring is substituted with halogen atoms (e.g., chlorine or bromine).
Cyclization: In certain conditions, nipecotic acid can undergo intramolecular cyclization reactions to form cyclic compounds.
Oxidation: Conversion of the piperidine ring or the carboxylic acid group into oxidized derivatives, such as N-oxides or carboxylic acid derivatives.
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1-Methylpiperidine-3-carboxylic acid hydrochloride
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1-Methylpiperidine-3-carboxylic acid
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rel-(3R,5S)-1-(tert-Butoxycarbonyl)piperidine-3,5-dicarboxylic acid
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1-(tert-Butoxycarbonyl)-4,4-difluoropiperidine-3-carboxylic acid
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1-(tert-Butoxycarbonyl)-4-hydroxypiperidine-3-carboxylic acid
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(3R,6R)-6-Methylpiperidine-3-carboxylic acid hydrochloride
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(R)-Piperidine-3-carboxylic acid hydrochloride
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(S)-Piperidine-3-carboxylic acid hydrochloride
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