Chemistry Heterocyclic Building Blocks Triazoles 1-Benzyl-1H-1,2,4-Triazole

1-Benzyl-1H-1,2,4-Triazole

Acylation: 1-Benzyl-1H-1,2,4-triazole can react with acylating agents, such as acyl chlorides or anhydrides , to form acyl derivatives of the compound. For example, reaction with acetyl chloride would yield N-acetyl-1-benzyl-1H-1,2,4-triazole. Alkylation: The compound can be alkylated by treating it with alkyl halides or alkylating agents under appropriate conditions. This would result in the substitution of a hydrogen atom with an alkyl group. Nucleophilic Substitution: Depending on the reaction conditions, the compound may undergo nucleophilic substitution reactions. For example, it can react with nucleophiles like amines or alkoxides to replace the benzyl group. Reduction: 1-Benzyl-1H-1,2,4-triazole can be reduced to its corresponding secondary amine or further to the primary amine using reducing agents like lithium aluminum hydride (LiAlH4) or sodium borohydride (NaBH4). Oxidation: It can undergo oxidation reactions to form various products. For example, oxidation with strong oxidizing agents like potassium permanganate (KMnO4) or chromic acid (H2CrO4) may lead to the formation of different oxidation products. Heterocyclic Ring Transformations: Under certain conditions, 1-benzyl-1H-1,2,4-triazole can participate in ring-forming reactions to generate fused or bridged heterocyclic compounds. N-Debenzylation: The benzyl group in the compound can be removed using deprotection reagents like hydrogenation (Pd/C, H2 gas) or strong acids to yield the corresponding 1H-1,2,4-triazole derivative. Condensation Reactions: 1-Benzyl-1H-1,2,4-triazole can participate in condensation reactions with carbonyl compounds or other electrophiles to form various heterocyclic compounds.

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(5As,10Br)-2-Phenyl-2,5A,6,10B-Tetrahydro-4H-Indeno[2,1-B][1,2,4]Triazolo[4,3-D][1,4]Oxazin-11-Ium 1-(Phenylsulfonyl)-1H-1,2,4-Triazole 1-Benzyl-1H-1,2,3-Triazole 1-Benzyl-1H-1,2,4-Triazole 1-Methyl-1H-1,2,3-Triazole 1-Methyl-1H-1,2,4-Triazole 1-Methyl-1H-Benzo[D][1,2,3]Triazole 1-Phenethyl-1H-1,2,4-Triazole 1-Phenyl-1H-1,2,3-Triazole 1-Phenyl-1H-1,2,4-Triazole 1H-1,2,4-Triazol-3-Amine 1H-1,2,4-Triazol-5-Amine 1H-Benzo[D][1,2,3]Triazol-1-Ol 2-Bromo-[1,2,4]Triazolo[1,5-A]Pyridine 2-Phenyl-2,5,6,7-Tetrahydropyrrolo[2,1-C][1,2,4]Triazol-4-Ium 2-Phenyl-2H-1,2,3-Triazole 2-Phenyl-2H-Benzo[D][1,2,3]Triazole 2H-1,2,3-Triazole 4-(4-Cyclopropylnaphthalen-1-Yl)-4H-1,2,4-Triazole 4-Phenyl-4H-1,2,4-Triazole 4-Phenyl-6H-Thieno[3,2-F][1,2,4]Triazolo[4,3-A][1,4]Diazepine 4H-1,2,4-Triazole 5-Bromo-1H-1,2,4-Triazole 5-Bromo-1H-Benzo[D][1,2,3]Triazole 5-Fluoro-1H-Benzo[D][1,2,3]Triazole 6-Bromo-[1,2,4]Triazolo[1,5-A]Pyridine 6-Bromo-[1,2,4]Triazolo[4,3-A]Pyridine 8-Bromo-[1,2,4]Triazolo[1,5-A]Pyridine [1,2,4]Triazolo[1,5-A]Pyrazine [1,2,4]Triazolo[1,5-A]Pyridin-2-Amine [1,2,4]Triazolo[4,3-A]Pyridin-3-Ylmethanamine Ethyl 1H-1,2,4-Triazole-3-Carboxylate

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