Home Chemistry Heterocyclic Building Blocks Azetidines 1-(Azetidin-3-Yl)-1H-Pyrazole
Nucleophilic Substitution: The azetidine ring contains a potential leaving group (the nitrogen atom) that can undergo nucleophilic substitution reactions. For example, you can react it with a nucleophile to replace the azetidine nitrogen with the nucleophile.
Acylation: You can treat 1-(azetidin-3-yl)-1H-pyrazole with acylating agents (such as acyl chlorides or anhydrides) to introduce acyl groups onto the nitrogen atoms of the azetidine and pyrazole rings.
Ring Opening: The azetidine ring can undergo ring-opening reactions under specific conditions, leading to the formation of new compounds. For example, it can be opened by strong nucleophiles.
Condensation Reactions: You can perform condensation reactions with this compound to form new heterocyclic compounds or add additional substituents to the rings.
Cyclization Reactions: Under specific conditions and with appropriate reagents, you can promote cyclization reactions to form new ring systems.
Substitution Reactions: The pyrazole ring can undergo substitution reactions at various positions, depending on the reagents and conditions used.
Metalation: You can metalate specific positions in the molecule by using strong bases and then react the resulting intermediates with various electrophiles.
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4-Amino-1-(1-boc-azetidin-3-yl)-1H-pyrazole
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tert-Butyl 3-(4-bromo-1H-pyrazol-1-yl)azetidine-1-carboxylate
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tert-Butyl 3-(4-iodo-1H-pyrazol-1-yl)azetidine-1-carboxylate
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1-(Azetidin-3-yl)-1H-pyrazole dihydrochloride
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tert-Butyl 3-(3-amino-1H-pyrazol-1-yl)azetidine-1-carboxylate
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1-(Azetidin-3-yl)-4-iodo-1H-pyrazole hydrochloride
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tert-Butyl 3-(4-nitro-1H-pyrazol-1-yl)azetidine-1-carboxylate
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