Home Chemistry Heterocyclic Building Blocks Piperazines (R)-2-Benzylpiperazine
Acylation: (R)-2-benzylpiperazine can undergo acylation reactions, where an acyl group (-CO-R) is introduced onto the nitrogen atom. This is often done using acyl chlorides or anhydrides as acylating agents and a suitable base or catalyst.
Alkylation: The nitrogen atom in (R)-2-benzylpiperazine can be alkylated with alkyl halides or other alkylating agents. This reaction can introduce various alkyl groups onto the piperazine ring.
Reductive Amination: It can participate in reductive amination reactions, where it reacts with carbonyl compounds in the presence of reducing agents (e.g., sodium cyanoborohydride) to form secondary or tertiary amines.
Nucleophilic Substitution: Depending on the conditions, (R)-2-benzylpiperazine can undergo nucleophilic substitution reactions at the nitrogen atom with suitable electrophiles.
Oxidation: The benzyl group in (R)-2-benzylpiperazine can be oxidized to form a benzyl ketone using various oxidizing agents, such as potassium permanganate or chromium(VI) reagents.
Ring Opening: Under certain conditions, the piperazine ring can undergo ring-opening reactions to form open-chain compounds.
Cross-Coupling Reactions: It can be used in cross-coupling reactions, such as Suzuki-Miyaura, Heck, or Stille reactions, to form carbon-carbon or carbon-heteroatom bonds with suitable coupling partners.
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(R)-tert-Butyl 2-benzylpiperazine-1-carboxylate hydrochloride
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(R)-tert-Butyl 2-benzylpiperazine-1-carboxylate
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tert-Butyl (R)-2-benzyl-4-methylpiperazine-1-carboxylate hydrochloride
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