Sphingosine acyltransferase is a type of enzyme involved in the metabolism of sphingolipids, responsible for transferring fatty acyl groups onto sphingosine to form ceramides. This enzyme family includes several members, such as ceramide synthase 1 (CerS1) to CerS6, which differ in tissue expression and substrate specificity. These enzymes are primarily located in the endoplasmic reticulum and Golgi apparatus and are widely present in various cells and tissues. Sphingosine acyltransferase plays a crucial role in processes such as cell membrane stability, signal transduction, and cell proliferation. The specific expression and mutations of the gene are associated with various diseases, including cancer, neurodegenerative diseases, and skin diseases.