Home Chemistry Heterocyclic Building Blocks Indazoles 4,5,6,7-Tetrahydro-1H-Indazole
Substitution Reactions: The aromatic ring in 4,5,6,7-tetrahydro-1H-indazole can undergo electrophilic aromatic substitution reactions. For example, you can perform nitration (with nitric acid) or halogenation (with halogenating agents like bromine or chlorine) on the aromatic ring.
Reduction Reactions: The double bond in the indazole ring can be reduced to a single bond using reducing agents like hydrogen gas in the presence of a metal catalyst (e.g., Pd/C) or chemical reducing agents like sodium borohydride.
Oxidation Reactions: The indazole ring can be oxidized to form various functional groups. For example, you can oxidize it to a N-oxide using a peracid like m-chloroperoxybenzoic acid (MCPBA).
Acylation and Alkylation: The nitrogen atoms in the indazole ring can undergo acylation and alkylation reactions. For example, you can react it with acyl halides or alkyl halides in the presence of a base to introduce acyl or alkyl groups to the nitrogen atoms.
Cycloaddition Reactions: You can also perform various cycloaddition reactions, such as Diels-Alder reactions, with 4,5,6,7-tetrahydro-1H-indazole, depending on the reactants and reaction conditions.
Functional Group Transformations: Various functional groups can be introduced, modified, or transformed using appropriate reagents and reaction conditions, including amination, bromination, chlorination, and other reactions.
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3-Bromo-4,5,6,7-tetrahydro-1H-indazole
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4,5,6,7-Tetrahydro-1H-indazole-3-carboxylic acid
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4,5,6,7-Tetrahydro-1H-indazole-5-carboxylic acid
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Ethyl 4,5,6,7-tetrahydro-1H-indazole-5-carboxylate
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tert-Butyl (4,5,6,7-tetrahydro-1H-indazol-5-yl)carbamate
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Ethyl 4,5,6,7-tetrahydro-1H-indazole-3-carboxylate
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3-Iodo-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazole
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(S)-4,5,6,7-Tetrahydro-1H-indazol-5-amine hydrochloride
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(R)-4,5,6,7-Tetrahydro-1H-indazol-5-amine hydrochloride
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4,5,6,7-Tetrahydro-1H-indazol-5-amine dihydrochloride
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Ethyl 6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazole-3-carboxylate
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