Home Chemistry Heterocyclic Building Blocks Aliphatic Heterocycles 1,4-Oxazepane
Ring Opening:1,4-Oxazepane can undergo ring-opening reactions when treated with strong nucleophiles, such as Grignard reagents or organolithium compounds. The nucleophile attacks the electrophilic carbon in the ring, leading to the formation of an open-chain compound.
Nucleophilic Substitution:1,4-Oxazepane can undergo nucleophilic substitution reactions at the nitrogen or oxygen atoms in the ring. This typically occurs in the presence of a strong nucleophile and an appropriate leaving group. For example, an amine or alkoxide ion can displace a leaving group from the ring.
Electrophilic Addition:If 1,4-oxazepane is treated with electrophiles, such as acids or alkylating agents, it can undergo electrophilic addition reactions. For instance, the nitrogen or oxygen atoms can be protonated by an acid, or they can be alkylated by an alkyl halide.
Oxidation:1,4-Oxazepane can be oxidized under suitable conditions. Oxidation may involve breaking the ring and introducing oxygen-containing functional groups into the structure.
Reduction:Reduction reactions can also be performed on 1,4-oxazepane to reduce the oxygen or nitrogen atoms within the ring. For example, catalytic hydrogenation can be used to reduce the ring, forming a saturated compound.
Cyclization:In some cases, 1,4-oxazepane can be used as a starting material to synthesize other heterocyclic compounds. Intramolecular reactions can be carried out to form different ring structures.
Functional Group Transformation:Various functional group transformations, such as acylation, alkylation, or halogenation, can be performed on 1,4-oxazepane to modify its chemical structure.
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6-Methyl-1,4-oxazepan-6-ol hydrochloride
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(S)-tert-butyl 6-hydroxy-1,4-oxazepane-4-carboxylate
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(R)-tert-Butyl 6-hydroxy-1,4-oxazepane-4-carboxylate
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tert-Butyl 6-hydroxy-1,4-oxazepane-4-carboxylate
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(S)-4-(tert-Butoxycarbonyl)-1,4-oxazepane-2-carboxylic acid
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4-(tert-Butoxycarbonyl)-1,4-oxazepane-2-carboxylic acid
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