CD47, also known as integrin-associated protein, is a transmembrane protein consisting of an extracellular region, five transmembrane structures, and a short cytoplasmic tail. It is widely expressed in various cells and tissues, including red blood cells, white blood cells, and tumor cells. CD47 participates in regulating the phagocytic activity of immune cells by interacting with its ligand SIRPα, affecting tumor immune evasion and inflammatory responses. Additionally, CD47 is involved in biological processes such as cell migration and apoptosis. Specific gene expression and mutations in CD47 are associated with various diseases, including cancer, cardiovascular diseases, and autoimmune diseases.