Home Chemistry Heterocyclic Building Blocks Pyridines 2-Chloro-3-Fluoropyridine
Nucleophilic Substitution: The chlorine atom can be replaced by a nucleophile (e.g., amines, thiols, alcohols) to yield substituted pyridine derivatives.
Metalation: The pyridine ring can be deprotonated by strong bases, leading to the formation of metal pyridine complexes. This metalation can facilitate further reactions, such as cross-coupling reactions.
Reduction: The halogen substituents can be reduced to corresponding hydrogen atoms using reducing agents like lithium aluminum hydride (LiAlH4) or hydrogen gas (H2) in the presence of a catalyst.
Cross-Coupling Reactions: The compound can participate in various cross-coupling reactions, such as Suzuki coupling, Heck reaction, or Stille coupling, where the halogen atom serves as a leaving group and reacts with an appropriate coupling partner (e.g., boronic acids, olefins, organostannanes) to form new carbon-carbon bonds.
Electrophilic Aromatic Substitution: The pyridine ring can undergo electrophilic aromatic substitution reactions where electron-deficient species react with the aromatic ring. For instance, it can react with electrophiles such as acyl chloride, alkyl halides, or nitro compounds.
Halogenation: The compound can undergo halogenation reactions under appropriate conditions, leading to the introduction of additional halogen atoms onto the pyridine ring.
Oxidation: The compound can be oxidized under suitable conditions to yield pyridine N-oxides or other oxidized derivatives.
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2-Chloro-3-fluoropyridine-4-carbaldehyde
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2-Chloro-3-fluoro-5-(trifluoromethyl)pyridine
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(6-Chloro-5-fluoropyridin-3-yl)boronic acid
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