Home Chemistry Heterocyclic Building Blocks Azetidines Benzyl Azetidine-1-Carboxylate
Reduction: The carbonyl group in the azetidine-1-carboxylate moiety can be reduced to the corresponding alcohol using reducing agents like lithium aluminum hydride (LiAlH4) or sodium borohydride (NaBH4).
Amination: The benzyl group can be substituted with other amine groups through nucleophilic substitution reactions. For example, treating it with a primary amine and a suitable catalyst can lead to the formation of secondary amides.
Acylation: The azetidine-1-carboxylate moiety can undergo acylation reactions, where the carbonyl group is reacted with acylating agents like acyl chlorides or anhydrides to form amides.
Cyclization: Depending on the reaction conditions and reagents, benzyl azetidine-1-carboxylate may participate in cyclization reactions, forming different heterocyclic compounds.
Esterification: The carboxylic acid group in the azetidine-1-carboxylate can be esterified using alcohol and acid catalysts to produce benzyl azetidine-1-carboxylate esters.
Nucleophilic Substitution: The azetidine ring can undergo nucleophilic substitution reactions at the carbon adjacent to the nitrogen atom, leading to the formation of various derivatives.
Decarboxylation: Under certain conditions, such as high temperature or with appropriate reagents, the carboxyl group can undergo decarboxylation to give different products.
Amide Bond Formation: The compound can be used as a starting material for the synthesis of more complex molecules, particularly in the formation of amide bonds through peptide coupling reactions.
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benzyl 3-(chlorosulfonyl)azetidine-1-carboxylate
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benzyl 3-(aminomethyl)azetidine-1-carboxylate
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