Home Chemistry Organic Building Blocks Iodides 2-Iodo-6-Nitroaniline
These compounds have the same murcko framework: benzene,and at least 3 kinds of functional groups( —I,—NH2,—NO2).
Electrophilic Aromatic Substitution (EAS): Iodobenzene can undergo typical electrophilic aromatic substitution reactions, similar to benzene. The presence of the iodine atom makes the ring more reactive toward electrophiles due to its electron-donating inductive effect. Common EAS reactions include nitration, halogenation, sulfonation, and Friedel-Crafts reactions.
Coupling Reactions: Aniline can participate in coupling reactions, such as Ullmann coupling, Buchwald-Hartwig coupling, and others, to form C-N bonds with various partner molecules.
Reduction: The nitro group in nitrobenzene can be reduced to an amino group (-NH2) using reducing agents like iron and hydrochloric acid, or more commonly, using catalytic hydrogenation. This reaction produces aniline.
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