Home Chemistry Heterocyclic Building Blocks Indazoles 1H-Indazole-3-Carbonitrile
Substitution Reactions: The cyano group (-CN) can undergo substitution reactions with various nucleophiles or electrophiles to form substituted products.
Reduction: The carbonitrile group can be reduced to the corresponding primary amine using reducing agents such as lithium aluminum hydride or hydrogen gas over a metal catalyst.
Hydrolysis: The carbonitrile group can undergo hydrolysis under acidic or basic conditions to yield the corresponding carboxylic acid or amide, respectively.
Nucleophilic Addition: The carbonitrile group can undergo nucleophilic addition reactions with nucleophiles such as Grignard reagents or organolithium compounds to form carbon-carbon bonds.
Functional Group Interconversion: The carbonitrile group can be converted into other functional groups, such as carboxylic acids, esters, or amides, through appropriate reactions.
Cyclization Reactions: 1H-indazole-3-carbonitrile can participate in cyclization reactions to form fused ring systems or heterocyclic compounds.
Metalation: The indazole ring can undergo metalation reactions with strong bases to form metal complexes, which can further participate in various reactions.
Oxidation: The nitrogen-containing heterocycle can be oxidized under suitable conditions to form N-oxides or other oxidized derivatives.
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