RXFP receptors are a group of receptors that bind to relaxin-related peptides, including four subtypes: RXFP1 to RXFP4. They have a N-terminal extracellular domain and seven transmembrane domains. RXFP receptors are mainly expressed in the cardiovascular system, reproductive system, and central nervous system. They participate in regulating processes such as blood pressure, cardiac function, reproduction, and neural regulation by recognizing relaxin and related peptides. RXFP receptors activate multiple signaling pathways, including cAMP, IP3, and MAPK. Mutations or abnormal expression of RXFP receptors are associated with the development of cardiovascular diseases, reproductive disorders, and neurological and psychiatric disorders.