Home Chemistry Organic Building Blocks Fluorinated Building Blocks 1,2-Difluoro-3-Methoxybenzene
These compounds have the same murcko framework: benzene,and at least 2 kinds of functional groups( —F,—OCH3).
Electrophilic Aromatic Substitution (EAS): Fluorobenzene can undergo typical electrophilic aromatic substitution reactions, similar to benzene. The fluorine atom, being electron-withdrawing, can influence the reactivity of the benzene ring. Common EAS reactions include nitration, halogenation, sulfonation, and Friedel-Crafts reactions.
Borohydride Demethylation: Methoxybenzene can undergo demethylation reactions using sodium borohydride (NaBH4) in the presence of a proton source, resulting in the formation of phenol.
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(2,3-Difluoro-4-methoxyphenyl)methanol
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(2,3-Difluoro-4-methoxyphenyl)boronic acid
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2-(2,3-Difluoro-4-methoxyphenyl)acetonitrile
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(3,4-Difluoro-2-methoxyphenyl)boronic acid
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