Apoptosis Inducers are factors that activate the cellular self-destruct program. These factors include proteins such as caspase activators, p53 protein, and TNF-related apoptosis-inducing ligand (TRAIL). They are localized in various cell components, including the cytoplasm, mitochondria, and cell membrane. These factors promote programmed cell death by activating apoptotic signaling pathways, including intrinsic and extrinsic pathways. Gene expression is tightly regulated, and mutations can lead to apoptosis dysregulation, associated with the development of various diseases.