Home Chemistry Heterocyclic Building Blocks Cinnolines Cinnoline
Acylation: Cinnoline can be acylated by reaction with acyl chlorides or anhydrides, leading to the formation of cinnoline derivatives with acyl groups attached to the nitrogen atom. For example, acetylation with acetyl chloride can yield acetylcinnoline.
Alkylation: Cinnoline can undergo alkylation reactions with alkyl halides or alkylating agents. This results in the introduction of alkyl groups onto the nitrogen atom, leading to various alkylcinnoline derivatives.
Sulfonation: Cinnoline can be sulfonated by reacting it with concentrated sulfuric acid. This reaction introduces a sulfonyl group onto the cinnoline ring, leading to the formation of sulfonated cinnoline compounds.
Halogenation: Cinnoline can undergo halogenation reactions by reacting with halogens (e.g., chlorine or bromine) or their derivatives. Halogenation can occur at various positions on the cinnoline ring, depending on the specific conditions and reagents.
Oxidation: Cinnoline can be oxidized by various oxidizing agents, leading to the formation of oxidation products. The specific products will depend on the choice of oxidizing agent and reaction conditions.
Reduction: Reduction reactions of cinnoline can be achieved using reducing agents like lithium aluminum hydride (LiAlH4) or sodium borohydride (NaBH4). This can lead to the formation of reduced cinnoline derivatives.
Cross-coupling reactions: Cinnoline derivatives can be used in various cross-coupling reactions, such as Suzuki-Miyaura, Heck, or Stille reactions, to form more complex molecules.
Substitution reactions: Cinnoline can undergo nucleophilic aromatic substitution reactions, where substituents can be introduced on the aromatic ring under appropriate reaction conditions.
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