Home Chemistry Heterocyclic Building Blocks Indoles Tert-Butyl 3-Iodo-1H-Indole-1-Carboxylate
Nucleophilic Substitution: The iodine atom is a good leaving group. The compound may undergo nucleophilic substitution reactions with nucleophiles (e.g., amines, thiols) to replace the iodine atom.
Palladium-Catalyzed Cross-Coupling Reactions: The presence of an iodine atom makes this compound suitable for palladium-catalyzed cross-coupling reactions, such as Suzuki, Stille, or Heck reactions. These reactions can be used to form carbon-carbon bonds.
Reduction: The ester functional group can be reduced to the corresponding alcohol under appropriate conditions, such as using a reducing agent like lithium aluminum hydride (LiAlH4) or sodium borohydride (NaBH4).
Amination Reactions: The compound may undergo amination reactions, where the amino group is introduced through the replacement of the iodine atom with an amine group.
Hydrolysis: The ester functional group may undergo hydrolysis under acidic or basic conditions to form the corresponding carboxylic acid and alcohol
Cyclization Reactions: The presence of the indole ring suggests the possibility of cyclization reactions under certain conditions.
Substitution Reactions at the Indole Ring: The indole ring can undergo substitution reactions, where a nucleophile replaces a hydrogen atom on the indole ring.
Oxidation: The tert-butyl group or the indole ring can be oxidized under specific conditions.
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