Chemistry Heterocyclic building blocks Piperidines Piperidin-3-ylmethanol

Piperidin-3-ylmethanol

These compounds have the same murcko framework: piperidin-3-ylmethanol

Acid-Catalyzed esterification: Piperidin-3-ylmethanol can undergo esterification reactions with carboxylic acids in the presence of an acid catalyst to form piperidin-3-ylmethyl esters.
Oxidation: Under certain conditions, piperidin-3-ylmethanol can undergo oxidation reactions to form piperidin-3-yl aldehydes or carboxylic acids.
Reduction: It can also undergo reduction reactions to form piperidin-3-ylmethyl amines.
Substitution Reactions: Piperidin-3-ylmethanol may undergo substitution reactions at the hydroxyl group or at the nitrogen atom of the piperidine ring, depending on the reaction conditions and the nature of the reacting species.
Formation of Imine: Piperidin-3-ylmethanol can react with carbonyl compounds to form imine derivatives.
Nucleophilic Addition: The hydroxyl group of piperidin-3-ylmethanol can undergo nucleophilic addition reactions with electrophiles.
Ring-Opening Reactions: Piperidin-3-ylmethanol can participate in ring-opening reactions under suitable conditions.
Alkylation: It can undergo alkylation reactions, where alkyl groups are introduced onto the nitrogen atom or onto the oxygen atom of the hydroxyl group.

Further Reading:

Framework+−

(9h-fluoren-9-yl)methyl piperidine-1-carboxylate (e)-n-(3-oxo-1-phenyl-3-(piperidin-1-yl)prop-1-en-2-yl)benzamide (r)-2-phenylpiperidine (r)-3-aminopiperidin-2-one (r)-n-(piperidin-3-yl)-7h-pyrrolo[2,3-d]pyrimidin-4-amine (s)-2-phenylpiperidine (s)-n-phenylpiperidine-2-carboxamide 1,3-dihydrospiro[indene-2,4'-piperidine] 1,4'-bipiperidine 1-((benzyloxy)carbonyl)piperidine-2-carboxylic acid 1-((benzyloxy)carbonyl)piperidine-3-carboxylic acid 1-(methylsulfonyl)piperidine 1-(phenylsulfonyl)piperidine 1-(piperidin-1-yl)ethan-1-one 1-(piperidin-4-yl)piperazine 1-benzyl 3-methyl piperidine-1,3-dicarboxylate 1-benzyl-n-methylpiperidin-3-amine 1-benzylpiperidin-3-one 1-benzylpiperidin-4-amine 1-benzylpiperidin-4-one 1-isopropylpiperidine 1-methyl-4-phenylpiperidine 1-methylpiperidin-2-one 1-oxa-8-azaspiro[4.5]decane 1-phenylpiperidin-2-one 2,2-dimethylpiperidin-4-one 2,2-dimethylpiperidine 2,7-diazaspiro[3.5]nonane 2,8-diazaspiro[4.5]decan-3-one 2,8-diazaspiro[4.5]decane 2-(piperidin-1-yl)ethan-1-amine 2-(piperidin-1-yl)ethan-1-ol 2-(piperidin-1-yl)pyridine 2-(piperidin-1-yl)pyrimidine 2-(piperidin-2-yl)ethan-1-ol 2-(piperidin-4-yl)ethan-1-ol 2-(piperidin-4-yl)pyridine 2-methylpiperidin-4-one 2-methylpiperidine 2-phenylpiperidine 3,3-difluoropiperidin-4-one 3,3-difluoropiperidine 3,3-dimethylpiperidin-4-one 3,3-dimethylpiperidine 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione 3-(piperidin-1-yl)pyridine 3-(piperidin-4-yl)-1h-indazole 3-(piperidin-4-yl)-1h-indole 3-(piperidin-4-yl)pyridine 3-fluoropiperidin-4-one 3-fluoropiperidine 3-methoxypiperidine 3-methylpiperidin-4-one 3-methylpiperidine 3-phenylpiperidine 4,4-difluoropiperidine 4-(1h-pyrazol-1-yl)piperidine 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,6-tetrahydropyridine 4-(azetidin-1-yl)piperidine 4-(benzyloxy)piperidine 4-(piperidin-1-yl)pyrimidine 4-(pyrrolidin-1-yl)piperidine 4-benzylpiperidine 4-hydrazineylpiperidine 4-hydroxypiperidin-2-one 4-methyl-1-phenylpiperidine 4-methylenepiperidine 4-oxopiperidine-2-carboxylic acid 4-phenylpiperidin-4-ol 5-hydroxypiperidin-2-one 6-azaspiro[2.5]octane 6-oxopiperidine-2-carboxylic acid 7-azaspiro[3.5]nonane Azepane Benzyl (r)-3-aminopiperidine-1-carboxylate Benzyl 3-hydroxypiperidine-1-carboxylate Benzyl 4-oxopiperidine-1-carboxylate Benzyl piperidin-4-ylcarbamate Benzyl piperidine-1-carboxylate Benzyl-3-aminopiperidine-1-carboxylate Ethyl piperidine-1-carboxylate Ethyl piperidine-2-carboxylate Ethyl piperidine-3-carboxylate Ethyl piperidine-4-carboxylate Methyl 4-oxopiperidine-2-carboxylate Methyl piperidine-2-carboxylate Methyl piperidine-3-carboxylate N-benzylpiperidin-4-amine N-methylpiperidin-3-amine N-phenylpiperidin-4-amine N-phenylpiperidine-2-carboxamide Phenyl(piperidin-1-yl)methanone Phenyl(piperidin-4-yl)methanone Piperidin-2-ylmethanamine Piperidin-2-ylmethanol Piperidin-3-amine Piperidin-3-ol Piperidin-3-one Piperidin-3-ylmethanamine Piperidin-3-ylmethanol Piperidin-4-amine Piperidin-4-ol Piperidin-4-ylmethanamine Piperidin-4-ylmethanol Piperidine-2,4-dione Piperidine-2,6-dione Piperidine-2-carboxylic acid Piperidine-3-carboxamide Piperidine-3-carboxylic acid Piperidine-4-carboxylic acid Quinuclidine Spiro[benzo[d][1,3]oxazine-4,4'-piperidin]-2(1h)-one Spiro[chromane-2,4'-piperidin]-4-one Spiro[indene-2,4'-piperidin]-1(3h)-one Spiro[indoline-3,4'-piperidin]-2-one Spiro[indoline-3,4'-piperidine] Tert-butyl (2-oxopiperidin-3-yl)carbamate Tert-butyl (6-oxopiperidin-3-yl)carbamate Tert-butyl (piperidin-3-ylmethyl)carbamate Tert-butyl 2-oxopiperidine-1-carboxylate Tert-butyl 3-bromopiperidine-1-carboxylate Tert-butyl 4-oxopiperidine-1-carboxylate Tert-butyl 4-phenoxypiperidine-1-carboxylate Tert-butyl 4-phenylpiperidine-1-carboxylate Tert-butyl piperidin-3-ylcarbamate

By Key Group+−

Acetylpiperidine Aminopiperidine Benzoylpiperidine Benzylpiperidine Bipiperidine Boc-piperidine Boronate-piperidine-carboxylate Bromopiperidine Carbamoylpiperidine Chloropiperidine Cyanopiperidine Cyclopropylpiperidin Difluoromethyl-piperidine Difluoropiperidine Dimethylpiperidine Dioxaborolane-piperidine Dioxopiperidine Ethylpiperidine Ethynylpiperidine Fluoropiperidine Formylpiperidine Hydroxyethyl-piperidine-carboxylate Hydroxymethyl-piperidine-carboxylate Hydroxypiperidine Indazole-piperidine-carboxylate Indoline-piperidine Isopropylpiperidine Methoxypiperidine Methylenepiperidine Methylpiperidine Oxoethyl-piperidine-carboxylate Oxopiperidine Pentamethylpiperidin Phenoxypiperidine Phenyl-sulfonyl-piperidine Phenylpiperidine Piperidin-amine Piperidin-imidazolyl Piperidine-benzimidazole Piperidine-benzofuran Piperidine-carboxylate Piperidine-carboxylate-hydrochloride Piperidine-carboxylic acid Piperidine-ethanol Piperidine-hydrochloride Piperidine-indole Piperidine-methanamine Piperidine-methanone Piperidine-nitrile Piperidine-piperidine Piperidine-propanol Piperidine-pyrimidine Piperidine-triazole Piperidineacetic Piperidinecarboxylate Piperidinecarboxylic Piperidinemethanol Piperidinone Piperidinyl-phenyl-boronic acid Piperidinyl-phenyl-boronic acid/ester Piperidinyl-phenyl-boronic-acid Propylpiperidine Pyrazole-piperidine Pyridin-piperidine Spiro-benzofuran-piperidine Tetrahydropyrazolopyridine Tetramethylpiperidine Trifluoromethyl-phenyl-piperidine Trifluoromethyl-piperidine

By Parent Nucleus+−

aliphatic heterocycles aromatic heterocycles azetidines benzimidazoles benzisoxazoles benzofurans benzoxazoles dioxolanes epoxides furans guanidines imidazoles imidazolidines imidazolines indazoles indoles indolines isoxazoles morpholines other aliphatic heterocycles other aromatic heterocycles oxadiazoles oxazines oxazolidines oxazolines oxetanes piperazines pyrazines pyrazoles pyridazines Pyridines Pyrimidines pyrrolidines quinazolines spiroes tetrahydrofurans tetrahydroisoquinolines tetrahydropyrans thiophenes triazoles

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acyl chlorides alcohols aldehydes aliphatic chain hydrocarbons aliphatic cyclic hydrocarbons alkenyls alkyls alkynyls amides amines aryls azoes benzyl chlorides bromides carboxylic acids Chiral building blocks chlorides difluoromethyls esters ethers fluorinated building blocks hydrazides hydrazines hydroxylamines iodides ketones nitriles nitroes oximes phenols phosphoruses sulfamides sulfonates sulfones sulfonic acids sulfonyl chlorides thioureas trifluoromethyls ureas

Heterocyclic related+−

Metal catalysts piperidines

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