Home Chemistry Heterocyclic Building Blocks Indazoles 6-Fluoro-1H-Indazole
Nucleophilic Substitution: The fluorine atom can undergo nucleophilic substitution reactions, where it is replaced by other nucleophiles such as hydroxide, alkoxides, or amines.
Electrophilic Substitution: The aromatic ring can undergo electrophilic substitution reactions, such as halogenation, nitration, sulfonation, or Friedel-Crafts acylation and alkylation.
Metalation: The indazole ring can be metalated by treatment with strong bases like butyllithium or sodium amide, leading to the formation of organometallic intermediates.
Reduction: The nitro group, if present, can be reduced to the corresponding amino group using reducing agents like hydrogen gas over a metal catalyst, tin(II) chloride, or iron filings with acid.
Oxidation: The indazole ring or functional groups attached to it can undergo oxidation reactions under suitable conditions, leading to the formation of various oxidation products.
Cycloaddition Reactions: indazole can participate in various cycloaddition reactions, such as [3+2] cycloadditions with azides, nitrile oxides, or other dipolarophiles.
Functional Group Transformations: Various functional groups present in 6-fluoro-1H-indazole can undergo transformations like esterification, amidation, acylation, or alkylation reactions.
Heterocyclic Chemistry: 6-fluoro-1H-indazole can participate in various heterocyclic chemistry reactions, such as ring-opening reactions, ring-closing reactions, or rearrangements.
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Methyl 6-fluoro-1H-indazole-5-carboxylate
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6-Fluoro-1H-indazole-5-carboxylic acid
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