WRN protein is a member of the RecQ helicase family, possessing both helicase and exonuclease activities. It is primarily localized in the nucleus and plays a crucial role in DNA replication, repair, and recombination, essential for maintaining genomic stability. WRN is expressed in various cell types, particularly abundant in rapidly dividing cells. Mutations in the WRN gene are closely linked to Werner syndrome, a premature aging disorder characterized by early-onset aging and an increased cancer propensity.