Home Chemistry Heterocyclic Building Blocks Pyrrolidines (S)-N-(4-(Thiazol-5-Yl)Benzyl)Pyrrolidine-2-Carboxamide
Acylation: The carboxamide group in the molecule can undergo acylation reactions with various acyl chlorides or anhydrides to form amides. For example, you can react it with acyl chlorides like acetyl chloride to obtain N-acylated derivatives.
Reduction: The molecule may be reduced using reducing agents like lithium aluminum hydride (LiAlH4) or sodium borohydride (NaBH4) to convert the amide functionality to the corresponding amine.
Cross-coupling Reactions: The benzyl group containing a thiazole ring can be functionalized through various cross-coupling reactions like Suzuki-Miyaura coupling or Heck reaction.
Protecting Group Chemistry: If necessary, functional groups within the molecule can be protected using appropriate protecting groups to facilitate specific transformations in multistep syntheses.
Ring-Opening Reactions: The pyrrolidine ring can undergo ring-opening reactions with suitable reagents, such as acids or nucleophiles, to yield open-chain derivatives.
Esterification: The carboxylic acid functionality, if generated through hydrolysis or some other means, can be converted into esters through esterification reactions.
Chiral Pool Synthesis: This chiral compound can be used as a starting material in the synthesis of other chiral molecules, especially in medicinal chemistry or asymmetric synthesis.
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