The SREBP (Sterol Regulatory Element-Binding Proteins) family includes members such as SREBP-1a, SREBP-1c, and SREBP-2, which are key transcription factors regulating lipid synthesis. These proteins exist as precursors in the endoplasmic reticulum and are activated in response to cellular cholesterol levels, then translocated to the nucleus to activate the expression of genes involved in lipid metabolism. SREBPs exhibit specific expression patterns in various tissues, particularly high in the liver and adipose tissue. Mutations or dysregulation in their expression are closely linked to several metabolic diseases, including obesity, type 2 diabetes, and cardiovascular diseases.