Home Chemistry Heterocyclic Building Blocks Quinolines 2-Phenylquinoline
Aromatic Electrophilic Substitution: 2-Phenylquinoline contains an aromatic ring, which can undergo electrophilic substitution reactions such as nitration, halogenation, sulfonation, and Friedel-Crafts acylation/alkylation. This is due to the presence of the aromatic system.
Reduction: The quinoline ring in 2-phenylquinoline can be reduced to dihydroquinoline using various reducing agents like hydrogen and a catalyst, or with metal hydrides like sodium borohydride.
Oxidation: 2-Phenylquinoline can be oxidized, leading to the formation of quinoline N-oxides or other oxidation products, depending on the conditions and reagents used.
Substitution at Nitrogen Atoms: The nitrogen atoms in the quinoline ring can undergo various nucleophilic substitution reactions, such as alkylation or acylation, depending on the reagents used.
Heterocyclic Chemistry: As a quinoline derivative, it can participate in various heterocyclic chemistry reactions, including condensations, ring-closure reactions, and modifications of the quinoline moiety.
Metal Complexation: 2-Phenylquinoline can act as a ligand and form complexes with transition metal ions, which can lead to various coordination chemistry reactions and catalytic processes.
Functional Group Transformations: You can also carry out reactions on the phenyl group, such as oxidation, reduction, and various substitution reactions, to modify the 2-phenylquinoline molecule.
Cross-Coupling Reactions: It can participate in cross-coupling reactions like Suzuki, Heck, or Stille coupling, which are widely used in organic synthesis to form C-C bonds.
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2-(3-Chlorophenyl)quinoline-4-carbonyl chloride
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2-(2-Methoxyphenyl)quinoline-4-carboxylic acid
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2-(4-Chlorophenyl)quinoline-4-carboxylic acid
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Methyl 2-(4-bromophenyl)quinoline-4-carboxylate
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2-(4-Bromophenyl)quinoline-4-carboxylic acid
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2-(4-Bromophenyl)-6-chloroquinoline-4-carboxylic acid
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