Chemistry Heterocyclic building blocks Pyrazoles 1,5-diphenyl-1h-pyrazole

1,5-diphenyl-1h-pyrazole

Substitution Reactions: The phenyl groups on the pyrazole ring can undergo substitution reactions. For example, you can perform electrophilic aromatic substitution reactions with reagents like acyl chlorides (Friedel-Crafts acylation) or nitration (to introduce nitro groups). Reduction: Reduction of the pyrazole ring can be achieved using reducing agents like lithium aluminum hydride (LiAlH4) to convert it to a corresponding piperidine derivative. Oxidation: Oxidation of 1,5-diphenyl-1H-pyrazole can yield various products, depending on the reaction conditions. For example, you can use strong oxidizing agents like potassium permanganate (KMnO4) to oxidize it to carboxylic acids or other functional groups. Alkylation: The pyrazole ring can undergo alkylation reactions, where alkyl halides or alkylating agents are used to introduce alkyl groups onto the ring. Acylation: The pyrazole ring can also undergo acylation reactions using acyl chlorides or anhydrides to introduce acyl groups. Heterocycle Formation: 1,5-diphenyl-1H-pyrazole can participate in reactions to form other heterocyclic compounds. Cross-Coupling Reactions: It can be used as a substrate in various cross-coupling reactions, such as Suzuki-Miyaura or Heck coupling, to introduce different substituents on the phenyl groups. Functional Group Interconversions: You can transform the compound by converting functional groups, such as converting one of the phenyl groups to a different functional group using appropriate reagents.

Further Reading:

Framework+−

(1-methyl-1h-pyrazol-3-yl)methanol (1-phenyl-1h-pyrazol-4-yl)boronic acid 1,3-dimethyl-1h-pyrazole 1,3-diphenyl-1h-pyrazole 1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole 1,5-diphenyl-1h-pyrazole 1-(2-chlorophenyl)-1h-pyrazole 1-(3-chlorophenyl)-1h-pyrazole 1-(4-methoxybenzyl)-1h-pyrazole 1-(azetidin-3-yl)-1h-pyrazole 1-(tetrahydro-2h-pyran-2-yl)-1h-pyrazole 1-(tetrahydro-2h-pyran-4-yl)-1h-pyrazole 1-benzyl-1h-pyrazolo[3,4-b]pyridine 1-benzyl-4-bromo-1h-pyrazole 1-benzyl-4-iodo-1h-pyrazole 1-cyclopentyl-1h-pyrazole 1-cyclopropyl-1h-pyrazole 1-methyl-1h-pyrazol-3-amine 1-methyl-3-phenyl-1h-pyrazole 1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1h-pyrazole 1-methyl-5-phenyl-1h-pyrazole 1-phenyl-1h-pyrazol-3-amine 1-phenyl-1h-pyrazol-3-ol 1-phenyl-1h-pyrazol-5-amine 1-phenyl-1h-pyrazole-3-carboxylic acid 1-phenyl-1h-pyrazole-4-carbaldehyde 1-phenyl-1h-pyrazole-4-carbonitrile 1-phenyl-1h-pyrazole-4-carboxylic acid 1-phenyl-1h-pyrazole-5-carboxylic acid 1-phenyl-3-(trifluoromethyl)-1h-pyrazole 1-trityl-1h-pyrazole 1h-pyrazol-4-amine 1h-pyrazol-4-ol 1h-pyrazol-5-amine 1h-pyrazole-4-carbaldehyde 1h-pyrazole-4-carbonitrile 1h-pyrazole-4-carboxylic acid 1h-pyrazole-4-sulfonyl chloride 1h-pyrazole-5-carboxamide 1h-pyrazole-5-carboxylic acid 1h-pyrazolo[3,4-b]pyrazine 1h-pyrazolo[3,4-b]pyridin-5-amine 1h-pyrazolo[3,4-d]pyrimidin-4-amine 1h-pyrazolo[4,3-d]pyrimidine 2,3-dihydropyrazolo[5,1-b]oxazole 2,4-dihydro-3h-pyrazol-3-one 2,6-di(1h-pyrazol-1-yl)pyridine 2-(1h-pyrazol-1-yl)pyridine 2-(1h-pyrazol-1-yl)pyrimidine 2-(1h-pyrazol-3-yl)pyridine 2-phenyl-2,4-dihydro-3h-pyrazol-3-one 3-(tert-butyl)-1-phenyl-1h-pyrazole 3-bromo-1-methyl-1h-pyrazole 3-bromopyrazolo[1,5-a]pyridine 3-bromopyrazolo[1,5-a]pyrimidine 3-chloro-1-methyl-1h-pyrazole 3-cyclopropyl-1h-pyrazole 3-iodo-1-methyl-1h-pyrazole 3-iodo-1h-pyrazolo[3,4-b]pyridine 3-methyl-1-phenyl-1h-pyrazole 3-phenyl-1h-pyrazol-5-amine 4,5,6,7-tetrahydro-1h-pyrazolo[3,4-c]pyridine 4,5,6,7-tetrahydro-1h-pyrazolo[4,3-c]pyridine 4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine 4-(1h-pyrazol-1-yl)benzoic acid 4-(1h-pyrazol-1-yl)piperidine 4-bromo-1-methyl-1h-pyrazole 4-bromo-1-phenyl-1h-pyrazole 4-bromo-1h-pyrazolo[3,4-b]pyridine 4-bromopyrazolo[1,5-a]pyridine 4-chloro-1h-pyrazole 4-chloro-1h-pyrazolo[3,4-b]pyridine 4-chloro-1h-pyrazolo[3,4-d]pyrimidine 4-iodo-1h-pyrazole 4-methyl-1-phenyl-1h-pyrazole 4-methyl-1h-pyrazole 4-nitro-1h-pyrazole 4-phenyl-1h-pyrazole 5,6-dihydro-4h-pyrrolo[1,2-b]pyrazole 5-(difluoromethyl)-1h-pyrazole 5-bromo-1h-pyrazole 5-bromo-1h-pyrazolo[3,4-b]pyridine 5-bromo-1h-pyrazolo[3,4-c]pyridine 5-chloro-1h-pyrazole 5-chloro-1h-pyrazolo[3,4-b]pyridine 5-chloropyrazolo[1,5-a]pyrimidine 5-cyclopropyl-1h-pyrazole 5-iodo-1h-pyrazole 5-nitro-1h-pyrazole 5-nitro-1h-pyrazolo[3,4-b]pyridine 5-phenyl-1h-pyrazole-3-carboxylic acid 6,7-dihydro-5h-pyrazolo[5,1-b][1,3]oxazine 6-bromopyrazolo[1,5-a]pyridine 6-bromopyrazolo[1,5-a]pyrimidine 6-chloro-1h-pyrazolo[3,4-d]pyrimidine 7-chloropyrazolo[1,5-a]pyrimidine Ethyl 1-phenyl-1h-pyrazole-3-carboxylate Ethyl 1-phenyl-1h-pyrazole-4-carboxylate Ethyl 1h-pyrazole-4-carboxylate Ethyl pyrazolo[1,5-a]pyridine-3-carboxylate Ethyl pyrazolo[1,5-a]pyrimidine-3-carboxylate Methyl 1h-pyrazole-4-carboxylate Methyl 1h-pyrazolo[3,4-b]pyridine-5-carboxylate Methyl pyrazolo[1,5-a]pyridine-3-carboxylate Pyrazolo[1,5-a]pyrazine Pyrazolo[1,5-a]pyridine-2-carboxylic acid Pyrazolo[1,5-a]pyridine-3-carboxylic acid Pyrazolo[1,5-a]pyrimidine-3-carboxylic acid Tert-butyl 1h-pyrazolo[3,4-b]pyridine-1-carboxylate Tert-butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1h-pyrazole-1-carboxylate

By Key Group+−

Amino-pyrazole-carboxylate Amino-pyrazolopyridine Aminopyrazolo Benzylpyrazol-amide Bipyrazole Bromo-methyl-pyrazole Bromo-pyrazol-amide Bromo-pyrazole-carboxylate Bromo-pyrazolopyridine Bromo-pyrazolopyrimidine Bromo-trifluoromethyl-pyrazole Bromopyrazolo Chloro-methyl-pyrazole Chloro-pyrazolamide Chloro-pyrazole Chloro-pyrazole-carboxylate Chloro-pyrazolopyridine Chloro-pyrazolopyrimidine Chloropyrazolo Dichloropyrazolo Difluoromethyl-pyrazole Difluoromethyl-pyrazole-carboxylate Dihydropyrazolo Dimethyl-pyrazol-amide Dimethyl-pyrazole-carboxylate Dimethyl-pyrazole-carboxylic acid Dimethylpyrazole Dimethylpyrazolo Dioxaborolan-pyrazole Ethyl-pyrazol-amide Ethylpyrazole Fluoropyrazolo Hydroxy-pyrazole Hydroxy-pyrazolopyrimidine Hydroxypyrazolo Iodo-methyl-pyrazole Iodo-pyrazole-carboxylate Iodopyrazolo Isopropyl-pyrazol-amide Methoxy-pyrazolo-pyridine Methoxypyrazolo Methy-pyrazolooxazine Methyl-hydrox-ypyrazole Methyl-nitro-pyrazole Methyl-pyrazol-one Methyl-pyrazole-carboxylic acid Methyl-pyrazole-carboxylic-acid Methyl-pyrazolone Methyl-pyrazolopyridine Methylpyrazole Methylpyrazolo Nitro-pyrazole-carboxylate Phenyl-pyrazol-amide Phenyl-pyrazole-carboxylate Phenyl-pyrazolidine Phenylpyrazole Pyrazo-morpholine Pyrazol-amine Pyrazol-boronic acid Pyrazol-methanol Pyrazol-one Pyrazol-piperazine Pyrazol-pyridine Pyrazole-carbonitrile Pyrazole-carboxylate Pyrazole-carboxylic acid Pyrazole-ethanol Pyrazole-hydrochloride Pyrazole-methamine Pyrazole-phenyl-boronic-acid Pyrazole-piperidine Pyrazolo-pyrimidine Pyrazolooxazine Pyrazolopyrazine Pyrazolopyridin-ol Pyrazolopyridin-one Pyrazolopyridine Pyrazolopyridine-carbonitrile Pyrazolopyridine-carboxylate Pyrazolopyridine-carboxylic acid Pyrazolopyridine-carboxylic-acid Pyrazolopyridine-methanol Pyrazolopyrimid-one Pyrazolopyrimidine Pyrazolotriazine Pyridine-pyrazole Pyrimidine-pyrazole Pyrrolopyrazole Tetrahydropyran-pyrazole Tetrahydropyranopyrazole Tetrahydropyrazolo Trifluoromethyl-phenyl-pyrazol Trifluoromethyl-pyrazol-amide Trifluoromethyl-pyrazole Trifluoromethyl-pyrazolone

By Parent Nucleus+−

aliphatic heterocycles aromatic heterocycles azetidines furans guanidines imidazoles indazoles indoles other aliphatic heterocycles other aromatic heterocycles oxetanes piperazines Piperidines pyrazines pyridazines Pyridines Pyrimidines pyrroles pyrrolidines quinolines tetrahydrofurans tetrahydropyrans thiophenes

By Functional Group+−

alcohols aldehydes aliphatic chain hydrocarbons aliphatic cyclic hydrocarbons alkenyls alkyls alkynyls amides amines aryls benzyl bromides benzyl chlorides bromides carboxylic acids Chiral building blocks chlorides difluoromethyls esters ethers fluorinated building blocks hydrazones iodides ketones nitriles nitroes oximes phenols phosphoruses sulfamides sulfides sulfonates sulfonic acids sulfonyl chlorides trifluoromethyls ureas

By Chemical Elements+−

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