AQP3 (Aquaporin 3) is a member of the Aquaporin (AQP) family, consisting of a water pore structure composed of six transmembrane domains and two NPA (Asn-Pro-Ala) sequences. AQP3 is primarily located in the cell membrane and is widely expressed in renal tubules, epidermal cells, and certain immune cells. AQP3 not only regulates the transmembrane transport of water but also participates in the transport of glycerol and some small molecules, affecting cell proliferation, migration, and skin hydration. The expression of AQP3 is tissue- and cell-specific, and mutations or dysregulation of its gene are associated with various diseases, including xeroderma, tumor development, and diabetes.