Home Chemistry Organic Building Blocks Bromides 2-Bromo-5-Fluoroaniline
These compounds have the same murcko framework: benzene,and at least 3 kinds of functional groups( —Br,—NH2,—F).
Grignard Reaction: Bromobenzene can react with a Grignard reagent (organomagnesium compound) to form a new carbon-carbon bond, leading to the introduction of various functional groups.
Coupling Reactions: Aniline can participate in coupling reactions, such as Ullmann coupling, Buchwald-Hartwig coupling, and others, to form C-N bonds with various partner molecules.
Electrophilic Aromatic Substitution (EAS): Fluorobenzene can undergo typical electrophilic aromatic substitution reactions, similar to benzene. The fluorine atom, being electron-withdrawing, can influence the reactivity of the benzene ring. Common EAS reactions include nitration, halogenation, sulfonation, and Friedel-Crafts reactions.
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Methyl 3-amino-2-bromo-5-fluorobenzoate
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