Home Chemistry Heterocyclic Building Blocks Pyrrolidines Phenyl(Pyrrolidin-1-Yl)Methanone
Reductive Amination: It can undergo reductive amination reactions with primary or secondary amines to form substituted amines. This reaction is often used in the synthesis of various compounds, including substituted pyrrolidines.
Nucleophilic Addition Reactions: The carbonyl group in phenyl(pyrrolidin-1-yl)methanone can undergo nucleophilic addition reactions with various nucleophiles such as Grignard reagents, organolithium compounds, or hydride reagents to form corresponding alcohol or substituted ketones.
Friedel-Crafts Acylation: Phenyl(pyrrolidin-1-yl)methanone can be used as an acylating agent in Friedel-Crafts acylation reactions, which can be used to introduce the phenyl(pyrrolidin-1-yl)methanone moiety onto aromatic rings.
Oxidation: Under appropriate conditions, the ketone group in this compound can be oxidized to form a carboxylic acid, which can further react with other compounds or be used in various synthetic pathways.
Reduction: The carbonyl group can be reduced to the corresponding alcohol using reducing agents like sodium borohydride or lithium aluminum hydride.
Alkylation: It can undergo alkylation reactions with alkyl halides or other alkylating agents to introduce alkyl groups to the molecule.
Cross-Coupling Reactions: Phenyl(pyrrolidin-1-yl)methanone can participate in cross-coupling reactions, such as Suzuki-Miyaura or Heck reactions, to form C-C bond connections with various aryl or alkyl groups.
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tert-Butyl 1-(4-(pyrrolidine-1-carbonyl)benzyl)hydrazinecarboxylate
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(4-(Hydrazinylmethyl)phenyl)(pyrrolidin-1-yl)methanone hydrochloride
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(2-Fluoro-5-(pyrrolidine-1-carbonyl)phenyl)boronic acid
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(3-Methoxyphenyl)(pyrrolidin-1-yl)methanone
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(3-(Pyrrolidine-1-carbonyl)phenyl)boronic acid
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(4-(Pyrrolidine-1-carbonyl)phenyl)boronic acid
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(2S,4S)-Methyl 4-amino-1-benzoylpyrrolidine-2-carboxylate hydrochloride
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(3-Nitro-5-(pyrrolidine-1-carbonyl)phenyl)boronic acid
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(4-Chloro-3-(pyrrolidine-1-carbonyl)phenyl)boronic acid
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(3-Fluoro-4-(pyrrolidine-1-carbonyl)phenyl)boronic acid
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