Chemistry Organic building blocks Fluorinated building blocks 2,3-difluorobenzoic acid

2,3-difluorobenzoic acid

These compounds have the same murcko framework: benzene,and at least 2 kinds of functional groups( —F,—COOH).

Electrophilic Aromatic Substitution (EAS): Fluorobenzene can undergo typical electrophilic aromatic substitution reactions, similar to benzene. The fluorine atom, being electron-withdrawing, can influence the reactivity of the benzene ring. Common EAS reactions include nitration, halogenation, sulfonation, and Friedel-Crafts reactions.
Friedel-Crafts Acylation: Benzoic acid can undergo Friedel-Crafts acylation reactions with aromatic compounds in the presence of a Lewis acid catalyst such as aluminum chloride (AlCl3). This reaction results in the introduction of an acyl group (RCO-) onto the aromatic ring.

Further Reading:

Framework+−

(2,3-difluorophenyl)boronic acid (2,6-difluorophenyl)boronic acid (2-chloro-6-fluorophenyl)boronic acid (2-fluorobenzyl)hydrazine (2-fluorophenyl)(phenyl)methanone (2-fluorophenyl)boronic acid (2-fluorophenyl)hydrazine (2-fluorophenyl)methanamine (2-fluorophenyl)methanol (3-fluorophenyl)(phenyl)methanone (3-fluorophenyl)boronic acid (3-fluorophenyl)methanol (4-fluorophenyl)(phenyl)methanone (4-fluorophenyl)boronic acid (4-fluorophenyl)methanamine (4-fluorophenyl)methanol 1,1-difluorocyclobutane 1,1-difluorocyclohexane 1,2,3,4,5-pentafluorobenzene 1,2,3,4-tetrafluorobenzene 1,2,3-trifluorobenzene 1,2,4-trifluorobenzene 1,2-dibromo-3-fluorobenzene 1,2-dibromo-4-fluorobenzene 1,2-dichloro-3-fluorobenzene 1,2-dichloro-4-fluorobenzene 1,2-difluoro-3-iodobenzene 1,2-difluoro-3-methoxybenzene 1,2-difluoro-3-methylbenzene 1,2-difluoro-3-nitrobenzene 1,2-difluoro-4-methoxybenzene 1,2-difluoro-4-nitrobenzene 1,2-difluorobenzene 1,3-dibromo-2,4-difluorobenzene 1,3-dibromo-2-fluorobenzene 1,3-dichloro-2-fluorobenzene 1,3-difluoro-2-iodobenzene 1,3-difluoro-2-methylbenzene 1,3-difluoro-2-nitrobenzene 1,4-dichloro-2-fluorobenzene 1,4-difluoro-2-iodobenzene 1,4-difluoro-2-nitrobenzene 1,4-difluorobenzene 1-(2-fluorophenyl)ethan-1-amine 1-(2-fluorophenyl)ethan-1-one 1-(2-fluorophenyl)piperazine 1-(2-fluorophenyl)propan-1-amine 1-(3-fluorophenyl)ethan-1-one 1-(4-fluorophenyl)ethan-1-one 1-(benzyloxy)-2-fluorobenzene 1-(benzyloxy)-3-fluorobenzene 1-(bromomethyl)-2-fluorobenzene 1-(bromomethyl)-3-fluorobenzene 1-(chloromethyl)-2-fluorobenzene 1-(chloromethyl)-3-fluorobenzene 1-benzyl-4-fluorobenzene 1-bromo-2,3-difluorobenzene 1-bromo-2,4-difluorobenzene 1-bromo-2-chloro-3-fluorobenzene 1-bromo-2-fluoro-3-methylbenzene 1-bromo-3-fluoro-2-methoxybenzene 1-bromo-3-fluoro-2-methylbenzene 1-bromo-3-fluoro-2-nitrobenzene 1-bromo-4-fluoro-2-methoxybenzene 1-bromo-4-fluoro-2-methylbenzene 1-chloro-2,3-difluorobenzene 1-chloro-2,4-difluorobenzene 1-chloro-3-fluoro-2-methoxybenzene 1-chloro-3-fluoro-2-methylbenzene 1-cyclohexyl-2-fluorobenzene 1-ethoxy-2,3-difluorobenzene 1-ethoxy-2-fluorobenzene 1-ethynyl-2-fluorobenzene 1-fluoro-2,3-dimethylbenzene 1-fluoro-2-(methylsulfonyl)benzene 1-fluoro-2-iodo-4-methylbenzene 1-fluoro-2-iodobenzene 1-fluoro-2-isopropoxybenzene 1-fluoro-2-methylbenzene 1-fluoro-2-phenoxybenzene 1-fluoro-3,5-dimethylbenzene 1-fluoro-3-(methylsulfonyl)benzene 1-fluoro-3-iodo-2-methylbenzene 1-fluoro-3-iodobenzene 1-fluoro-3-methoxybenzene 1-fluoro-3-methylbenzene 1-fluoro-3-nitrobenzene 1-fluoro-3-phenoxybenzene 1-fluoro-4-iodobenzene 1-fluoro-4-methoxybenzene 1-fluoro-4-methylbenzene 1-fluoro-4-phenoxybenzene 1-fluorobicyclo[1.1.1]pentane 1-fluoronaphthalene 2'-fluoro-1,1':4',1''-terphenyl 2,2',3,3',5,5',6,6'-octafluoro-1,1'-biphenyl 2,3-difluoroaniline 2,3-difluorobenzaldehyde 2,3-difluorobenzoic acid 2,3-difluorobenzonitrile 2,3-difluorophenol 2,3-difluoropyridine 2,4-dibromo-1-fluorobenzene 2,4-dichloro-1-fluorobenzene 2,4-difluoro-1-iodobenzene 2,4-difluoro-1-methoxybenzene 2,4-difluoro-1-nitrobenzene 2,4-difluoroaniline 2,4-difluorobenzaldehyde 2,4-difluorobenzoic acid 2,4-difluorobenzonitrile 2,4-difluorophenol 2,5-difluoroaniline 2,5-difluorobenzoic acid 2,5-difluoropyridine 2,6-difluoroaniline 2,6-difluorobenzaldehyde 2,6-difluorobenzoic acid 2,6-difluorobenzonitrile 2,6-difluorophenol 2,6-difluoropyridine 2-(2-fluorophenyl)acetic acid 2-(2-fluorophenyl)acetonitrile 2-(2-fluorophenyl)pyrrolidine 2-(3-fluorophenyl)acetic acid 2-(3-fluorophenyl)pyrrolidine 2-(4-fluorophenyl)-1h-indole 2-(4-fluorophenyl)acetic acid 2-(bromomethyl)-1,3-difluorobenzene 2-amino-2-(2-fluorophenyl)acetic acid 2-amino-3-(2-fluorophenyl)propanoic acid 2-amino-3-fluorobenzoic acid 2-bromo-1,3,4-trifluorobenzene 2-bromo-1,3-difluorobenzene 2-bromo-1,4-difluorobenzene 2-bromo-1-chloro-3-fluorobenzene 2-bromo-1-chloro-4-fluorobenzene 2-bromo-1-fluoro-4-methylbenzene 2-bromo-4-chloro-1-fluorobenzene 2-bromo-4-fluoro-1-methoxybenzene 2-bromo-4-fluoro-1-methylbenzene 2-bromo-4-fluoroaniline 2-bromo-4-fluorobenzaldehyde 2-bromo-4-fluorobenzonitrile 2-bromo-4-fluorophenol 2-bromo-5-fluoroaniline 2-bromo-5-fluorobenzaldehyde 2-bromo-5-fluorobenzoic acid 2-bromo-6-fluoroaniline 2-bromo-6-fluorophenol 2-chloro-1,3-difluorobenzene 2-chloro-1,4-difluorobenzene 2-chloro-3-fluoropyridine 2-chloro-4-fluoro-1-methoxybenzene 2-chloro-4-fluoroaniline 2-chloro-4-fluorobenzaldehyde 2-chloro-4-fluorobenzoic acid 2-chloro-4-fluorobenzonitrile 2-chloro-4-fluorophenol 2-chloro-5-fluoropyrimidine 2-chloro-6-fluoroaniline 2-chloro-6-fluorobenzoic acid 2-chloro-6-fluorobenzonitrile 2-chloro-6-fluorophenol 2-fluoro-1,3-dimethoxybenzene 2-fluoro-1,3-dimethylbenzene 2-fluoro-1-iodo-4-methylbenzene 2-fluoro-3-methylbenzaldehyde 2-fluoro-3-methylpyridine 2-fluoro-4-methoxyaniline 2-fluoro-4-methyl-1-nitrobenzene 2-fluoro-4-methylbenzoic acid 2-fluoro-4-methylpyridine 2-fluoro-5-methylpyridine 2-fluoro-6-methylpyridine 2-fluoro-n-methylbenzamide 2-fluoro-n-phenylaniline 2-fluoro-n-phenylbenzenesulfonamide 2-fluoroaniline 2-fluorobenzaldehyde 2-fluorobenzamide 2-fluorobenzenesulfonamide 2-fluorobenzenesulfonyl chloride 2-fluorobenzoic acid 2-fluoropyridine 2-fluoropyrimidine 3,3-difluoropiperidine 3,3-difluoropyrrolidine 3,4-difluoroaniline 3,4-difluorophenol 3,5-difluoropyridine 3-((tert-butoxycarbonyl)amino)-4-(2-fluorophenyl)butanoic acid 3-chloro-2-fluoroaniline 3-fluoro-1,1'-biphenyl 3-fluoro-2-iodoaniline 3-fluoro-2-methylaniline 3-fluoro-2-methylpyridine 3-fluoro-4-nitroaniline 3-fluoroaniline 3-fluorobenzaldehyde 3-fluorobenzamide 3-fluorobenzenesulfonyl chloride 3-fluorobenzoic acid 3-fluorophenol 3-fluoropiperidine 3-fluoropyridin-2-amine 3-fluoropyridin-4-amine 3-fluorothiophene 4,4-difluoropiperidine 4-(2-fluorophenyl)morpholine 4-(4-fluorophenyl)thiazole 4-chloro-5-fluoro-2-methylpyrimidine 4-fluoro-1-methyl-2-nitrobenzene 4-fluoro-1h-indazole 4-fluoro-1h-indole 4-fluoro-1h-pyrrolo[2,3-b]pyridine 4-fluoro-2-iodoaniline 4-fluoro-2-nitroaniline 4-fluoroaniline 4-fluorobenzaldehyde 4-fluorobenzamide 4-fluorobenzenesulfonyl chloride 4-fluorobenzo[d]thiazole 4-fluorobenzoic acid 4-fluorobenzonitrile 4-fluoroisoquinoline 4-fluorophenol 4-fluoropyrimidine 5-fluoro-1,2,3,4-tetrahydroisoquinoline 5-fluoro-1h-benzo[d][1,2,3]triazole 5-fluoro-1h-benzo[d]imidazole 5-fluoro-1h-indole 5-fluoro-1h-pyrrolo[2,3-b]pyridine 5-fluoro-2,3-dihydro-1h-indene 5-fluoro-2,3-dihydrobenzofuran 5-fluoro-2-methylpyridine 5-fluoro-3,4-dihydronaphthalen-1(2h)-one 5-fluorochromane 5-fluoroindoline 5-fluoroisoindolin-1-one 5-fluoropyridin-2-amine 5-fluoropyrimidine 6-fluoro-1,2,3,4-tetrahydroisoquinoline 6-fluoro-1,2,3,4-tetrahydroquinoline 6-fluoro-1h-indazole 6-fluoro-1h-indole 6-fluoro-1h-pyrrolo[2,3-b]pyridine 6-fluorobenzo[d]thiazole 6-fluorochromane 6-fluoropyridin-2-amine 6-fluoropyridin-3-amine 7-fluoro-1,2,3,4-tetrahydroisoquinoline 7-fluoro-1,2,3,4-tetrahydroquinoline 7-fluoro-1h-indazole 7-fluoro-1h-indole 7-fluorobenzo[d]thiazole 7-fluoroindoline-2,3-dione 7-fluoroisoquinoline 8-fluoro-3,4-dihydronaphthalen-1(2h)-one 8-fluorochromane 8-fluoroimidazo[1,2-a]pyridine 8-fluoroisoquinoline 8-fluoroquinazoline Benzenesulfonyl fluoride Ethyl 2-fluorobenzoate Ethyl 3-fluorobenzoate Fluorobenzene Methyl 2,6-difluorobenzoate Methyl 2-fluorobenzoate Methyl 3-fluorobenzoate Methyl 4-fluorobenzoate Methyl 6-fluoronicotinate N-(3-fluorophenyl)acetamide N-(4-fluorophenyl)benzamide Pentafluoro(phenyl)-l6-sulfane Phenyl trifluoromethanesulfonate Tert-butyl (4-fluorophenyl)carbamate Trifluoro(phenyl)borate

By Key Group+−

1,1-difluoroethyl 2,2-difluoroacetic acid 2,2-difluoroethoxy 2,2-difluoroethyl 2-bromo-1,1,2,2-tetrafluoroethoxy 2-fluoroethyl Bromo-fluorobenzene Carbonyl fluoride Chloro-fluoro-benzene Dichlorofluorobenzene Difluoro Difluoroaniline Difluorobenzaldehyde Difluorobenzamide Difluorobenzenesulfonamide Difluorobenzoate Difluorobenzylamine Difluorocyclobutanecarboxylate Difluoroethyl Difluoroethyl Difluoromethoxy Difluoromethoxy Difluoropiperidine Difluoropropan Difluoropropan Difluoropyrimidine Difluoroquinoline Ethyl 2,2-difluoro-acetate Fluindamine Fluindenamine Fluoro-benzenesulfonyl-chloride Fluoro-benzoimidazole Fluoro-dihydro-benzoxazine Fluoro-indazol-amine Fluoro-indazole-carboxylate Fluoro-indole-carboxylate Fluoro-methyl Fluoro-methyl-indazole Fluoro-naphthyridine Fluoro-phenyl-boronic acid Fluoro-pyrrolopyridine Fluoroacetanilide Fluoroacetophenone Fluoroaniline Fluoroanisole Fluorobenzaldehyde Fluorobenzamide Fluorobenzenesulfonamide Fluorobenzenethiol Fluorobenzimidamide Fluorobenzo Fluorobenzoate Fluorobenzoic Fluorobenzoyl Fluorobenzoyl-chloride Fluorobenzylamine Fluorobromobenzene Fluorocarboxylic acid Fluorochroman Fluorocinnamic Fluorocinnamic Fluorocinnamic acid Fluorocyclopropanecarboxylic Fluoroethoxy Fluoroethyl Fluoroethyl Fluoroimidazo Fluoroindan Fluoroindan Fluoroisonicotinaldehyde Fluoroisonicotinate Fluoroisonicotinic Fluoroisonicotinic acid Fluoromethyl Fluoromethyl Fluoromethyl-indole Fluoronicotinaldehyde Fluoronicotinamide Fluoronicotinate Fluoronicotinic Fluoronicotinic Fluoronicotinic acid Fluoronitrobenzene Fluorophenyl Fluorophenyl-borate Fluorophenyl-boronate Fluorophenylisocyanate Fluorophenylisothiocyanate Fluoropropan Fluoropropan Fluoropyrimidine Fluoroquinazoline Fluoroquinoline Fluorostyryl Fluorosulfonyl Fluorosulfonyl Fluorotoluene Heptadecafluorodecyl Heptafluoro Hexafluoro Hexafluoro Hexafluoropropan Hexafluoropropan Nonafluoro Nonafluoro Nonafluorobutane Nonafluorobutane Nonafluorohexyl Nonafluorohexyl Octafluoro Octafluoro Pentafluoro Pentafluorobenzoate Perfluorohexyl Perfluorohexyl Tetrafluoro Tetrafluoro Tetrafluoroaniline Tetrafluoroethoxy Tetrafluoroethoxy Tetrafluoropropyl Tetrafluoropropyl Tetrahydroquinoline-fluoro Tridecafluorooctyl Tridecafluorooctyl Trifluoro Trifluoro Trifluoroacetamide Trifluoroacetyl Trifluoroaniline Trifluorobenzaldehyde Trifluorobenzoate Trifluorobenzoylchloride Trifluorobut Trifluorobut Trifluorobutane Trifluorobutane Trifluoroethan Trifluoroethan Trifluoroethanamine Trifluoroethanol Trifluoroethoxy Trifluoroethoxy Trifluoroethyl Trifluoromethanesulfonamide Trifluoromethanesulfonyl Trifluoromethoxy Trifluoromethoxy Trifluoromethylthio Trifluoromethylthio Trifluoropropane Trifluoropropanoate Trifluoropropyl

By Parent Nucleus+−

Aliphatic heterocycles Aromatic heterocycles Azetidines Benzimidazoles Benzisoxazoles Benzofurans Benzothiazoles Benzothiophenes Benzoxazoles Carbazoles Dioxolanes Epoxides Furans Guanidines Imidazoles Imidazolines Indazoles Indoles Indolines Isoquinolines Isoxazoles Morpholines Naphthyridines Other aliphatic heterocycles Other aromatic heterocycles Oxadiazoles Oxazoles Oxazolidines Oxetanes Phthalazines Piperazines Piperidines Purines Pyrans Pyrazines Pyrazoles Pyridazines Pyridines Pyrimidines Pyrroles Pyrrolidines Pyrrolines Quinazolines Quinolines Quinoxalines Spiroes Tetrahydrofurans Tetrahydroisoquinolines Tetrahydropyrans Tetrahydroquinolines Thiazoles Thiazolidines Thiophenols Triazines Triazoles

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acyl chlorides alcohols aldehydes aliphatic chain hydrocarbons aliphatic cyclic hydrocarbons alkenyls alkyls alkynyls amides amidines Amines anhydrides Aryls benzyl bromides benzyl chlorides Bromides carboxylic acid salts carboxylic acids Chiral building blocks Chlorides difluoromethyls esters ethers hydrazides hydrazines iodides isocyanides ketones nitriles nitroes oximes phenols phosphoruses sulfamides sulfides sulfonates sulfones sulfonic acids sulfonyl chlorides thioesters thiols Thiophenes thioureas trifluoromethyls ureas

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