The Progesterone Receptor (PR) is a member of the nuclear receptor family, comprising two main forms: PR-A and PR-B. These receptors contain a ligand-binding domain, a DNA-binding domain, and a transcription activation domain. PR primarily localizes in the cell nucleus and regulates gene expression by binding to progesterone, participating in the regulation of the reproductive system, maintenance of pregnancy, menstrual cycle, and breast development. PR exhibits specific expression in the uterus, breast, central nervous system, and other tissues. Its activity and expression levels are regulated by hormonal cycles and physiological states. Mutations or dysregulation of the PR gene are associated with various reproductive health issues, including infertility, endometriosis, and breast cancer. The function and regulation of PR are crucial for female reproductive health.