Home Chemistry Heterocyclic Building Blocks Piperidines Piperidine-4-Carboxylic Acid
Acid-Base Reactions: As a carboxylic acid, piperidine-4-carboxylic acid can undergo acid-base reactions. In basic conditions, it will deprotonate to form the piperidine-4-carboxylate anion and a proton. In acidic conditions, it will protonate to form the corresponding protonated acid.
Esterification: piperidine-4-carboxylic acid can undergo esterification reactions with alcohols in the presence of acid catalysts. This reaction forms the corresponding ester along with water.
Amide Formation: piperidine-4-carboxylic acid can react with amines to form amides. This reaction involves the nucleophilic attack of the amine on the carbonyl carbon of the carboxylic acid group, followed by the elimination of water.
Decarboxylation: Under certain conditions, piperidine-4-carboxylic acid can undergo decarboxylation, resulting in the formation of piperidine, CO2, and water.
Substitution Reactions: piperidine-4-carboxylic acid can undergo substitution reactions at the piperidine ring if suitable conditions and reagents are provided.
Reduction: The carboxylic acid group of piperidine-4-carboxylic acid can be reduced to an alcohol group using reducing agents such as lithium aluminum hydride (LiAlH4) or sodium borohydride (NaBH4).
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1-(2,2,2-Trifluoroacetyl)piperidine-4-carboxylic acid
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Sodium 1-(prop-2-enoyl)piperidine-4-carboxylate
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1-Acryloylpiperidine-4-carboxylic acid
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1-Methylpiperidine-4-carboxylic acid hydrochloride
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1-Ethylpiperidine-4-carboxylic acid hydrochloride
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