Home Chemistry Organic Building Blocks Bromides 2-Bromo-6-(Trifluoromethyl)Aniline
These compounds have the same murcko framework: benzene,and at least 3 kinds of functional groups( —Br,—NH2,—CF3).
Electrophilic Aromatic Substitution (EAS): Bromobenzene can react with electrophiles in substitution reactions, such as nitration, sulfonation, halogenation, and Friedel-Crafts acylation/alkylation.
Schiff Base Formation: Aniline can react with 【aldehydes|https://www.ambeed.com/aldehydes.html】 and 【ketones|https://www.ambeed.com/ketones.html】 to form Schiff bases, which are important intermediates in organic synthesis.
Nucleophilic Aromatic Substitution (SNAr): Depending on the nature of the nucleophile, nucleophilic aromatic substitution reactions can occur. The trifluoromethyl group can influence the reactivity and regioselectivity of these reactions.
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2-Bromo-4-chloro-6-(trifluoromethyl)aniline
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2-Bromo-4-(perfluoropropan-2-yl)-6-(trifluoromethyl)aniline
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2-Bromo-4-nitro-6-(trifluoromethyl)aniline
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2-Bromo-4-fluoro-6-(trifluoromethyl)aniline
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