Home Life Science Inhibitors/Agonists Stem Cells BMI-1
BMI-1 serves as a crucial regulator of transcriptional silencing in development. It facilitates DNA end resection by promoting the recruitment of CtIP, enabling the accumulation of RPA and RAD51 at DNA damage sites. Notably, the use of transcription inhibitors restores the DNA end resection defects observed in BMI-1-depleted cells, indicating that BMI-1-dependent transcriptional silencing plays a role in mediating DNA end resection.
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