Home Chemistry Heterocyclic Building Blocks Indazoles 7-Fluoro-1H-Indazole
Substitution Reactions: The fluorine atom can undergo substitution reactions with various nucleophiles or electrophiles, leading to the formation of substituted indazoles.
Nucleophilic Substitution: The fluorine atom can be substituted by nucleophiles such as amines or alkoxides.
Metalation: The indazole ring can be metalated at the 2-position using strong bases such as butyllithium or sodium amide, allowing further functionalization.
Cross-Coupling Reactions: The fluorine atom can be replaced by coupling reactions such as Suzuki-Miyaura, Sonogashira, or Heck coupling, enabling the introduction of various functional groups.
Reduction: The fluorine atom can be reduced to hydrogen using appropriate reducing agents such as lithium aluminum hydride or hydrogen gas over a metal catalyst.
Oxidation: The indazole ring can undergo oxidation to form N-oxide derivatives using oxidizing agents such as m-chloroperoxybenzoic acid (mCPBA) or hydrogen peroxide.
Halogenation: Other halogens such as chlorine or bromine can be substituted for fluorine using halogenation reactions.
Cyclization Reactions: 7-fluoro-1H-indazole can participate in cyclization reactions to form fused ring systems or heterocyclic compounds.
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4,5,6,7-Tetrafluoro-3-methyl-1H-indazole
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7-Fluoro-1H-indazole-4-carboxylic acid
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Methyl 7-fluoro-1H-indazole-4-carboxylate
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