Home Chemistry Heterocyclic building blocks Pyridines N-phenylpyridin-2-amine
Acylation: N-Phenylpyridin-2-amine can undergo acylation reactions with acyl halides or anhydrides to form amides. For example, reacting it with acetyl chloride can yield N-phenyl-2-pyridinylacetamide.
Alkylation: It can be alkylated using alkyl halides or alkylating agents to introduce alkyl groups onto the amino nitrogen, forming N-alkylated derivatives.
Amination: N-Phenylpyridin-2-amine can undergo reductive amination reactions, where an aldehyde or ketone is reacted with the amine in the presence of a reducing agent to form secondary amines.
Arylation: It can undergo C-N bond formation reactions with aryl halides or arylboronic acids to introduce aryl groups onto the pyridine ring.
Heterocyclization: N-Phenylpyridin-2-amine can participate in heterocyclization reactions to form fused ring systems by reacting with appropriate reagents.
Reduction: The amino group can be reduced to the corresponding amine using reducing agents like hydrogen and a metal catalyst, or sodium borohydride.
Oxidation: The amine can be oxidized to the corresponding N-oxide or other oxidation products using appropriate oxidizing agents.
Condensation reactions: It can undergo condensation reactions with carbonyl compounds to form Schiff bases.
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